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Stem Cells and Their Clinical Application: Now and in Future
Stem Cells and Their Clinical Application: Now and in Future
Bone marrow
HSCs CD34+
MSCs CD34-
Embryonic stem cells (ESCs)
Transfer to uterus
• Can create
stem cells
directly from
a patient
• Can be
maintained
indefinitely in
the laboratory
• Pluripotent
with similar
properties to
ESCs
Image source: Robinton DA, Daley DQ. Nature 2012; 481, 295–305.
Different attributes
Capacity to produce
High High Low
diverse cell types
What makes stem cells so valuable?
Biology Applications
Li et al. Regen Med 2014; 9(1):27-39 (colours modified). Original data from www.clinicaltrials.gov
Originally published by Future Medicine – www.futuremedicine.com
Stem cell trials for cardiac disease: 1
• Korean study
– 96 treated (31 with erythropoietin & donor cord blood)
– Improvement in motor skills and cognitive function
Stem cell trials for stroke
NHMRC
www.nhmrc.gov.au/about/nhmrc-committees/embryo-research-licensing-
committee/human-embryos-and-cloning/stem-cells-clon
Regulatory frameworks elsewhere