Bioactive

Compound
Definition and assesment of activity

Vincentius Johar

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Hohenheim Consesus
Meeting
01 Invite many scientist to
discusss
02 Questions & Answer

03 Make a summary

04 Publish
 What are bioactive compounds?

Consensus: Bioactive compounds are essential and nonessential compounds (e.g., vitamins or
polyphenols) that occur in nature, are part of the food chain, and can be shown to have an effect
on human health

• Bioactive compounds are also referred to as nutraceuticals (reflect of existence biological activity of human)
• These individuals have a mutation in one enzyme or several enzymes involved in micronutrient metabolism or distribution
• Over the past decade, knowledge of the role of phytochemicals (e.g., polyphenols) in specific pathologies has advanced at an
accelerating pace.
 Bioactive compound
Nutraceuticals Daily Intake Mutation Phytochemicals
Studies to get lower risk molecular and cellular These individuals have a have been identified as
disease needs of the organism. mutation in one enzyme or having a preventive effect
several enzymes involved against specific diseases
in micronutrient metabolism
or distribution.

Traditional & Herbal

Bioavailability Consequently, Product innovations Fact about intake
investigation of an effect of the health benefits of potential medical and health High intake of vegetables is
a phytochemical at a very phytochemicals should be benefits. associated with a lower risk
early stage of disease evaluated of different kinds of cancer
development. using isolated compounds
BIOMARKER
Consensus:
A biomarker is a chemical or biological test result in an
analyzed biological material related to a certain exposure,
susceptibility, or biological effect.

Other Literature
‘‘Biomarker could be defined as a measurement made
on body tissue, body fluid or excretion to give a quantitative
indication of exposure to a chemical and which
may give an estimate of the risks consequent on that
exposure’’ , related to the subject of food chemistry

Other Literature
‘‘A biomarker is any substance, structure or process that
can be measured in the human body or its products and
may influence or predict the incidence or outcome of
disease’’ , related to cancer epidemiology

Other Literature
‘‘The biomarker would specifically and sensitively
reflect a disease state and could be used for diagnosis
as well as for disease monitoring during and following
therapy’’, related to therapy
TA B L E 1
 ‘‘biomarkers
have been defined
as indicators of
actual or possible
‘‘a biomarker is a changes of systemic
molecule that organ tissue,
indicates an cellular and sub-
alteration in cellular
physiology from structural and
normal having functional integrity
clinical utility’’ which can be used

1 2 3 4

‘‘the essential Any such results

qualities of must come from
biomarkers— tests that have been
responsiveness, validated according
specificity, ease of to methodologic
use, applicability practices and the
and relevance— ability of the
apply particularly in biomarker to actually
(diet and health)’’ reflect the exposure,
susceptibility, effect,
or risk as determined.
What are established
biomarkers of efficacy
with respect to health
effects?

Consesus
An established biomarker of efficacy is an
indicator of an improvement of a physiologic function or
a decrease in risk factors for a disease.
 However, for the reasons discussed, clinical endpoints appear less suitable
for studying the efficacy of bioactive substances, i.e., for prevention. We
therefore need to take a closer look at the concept of biomarkers and their
efficacy role in demonstrating the efficacy of bioactive substances.

Intervention studies may then be performed to demonstrate efficacy in

humans taking a specified amount of a bioactive substance each day under
precisely defined and controlled conditions

Human test

Extracts of plants or single compounds thereof that are believed to benefit

human health need to be identified and developed for the food market to
complement a balanced diet. (health effect)

Health from
nature
 The big point
The biomarker concept could be an essential element not
only in the efficacy testing of bioactive substances but also in
nutritional science in general. Using biomarkers, the moderate
effects of natural bioactive ingredients on the human body
could be studied without excessive strain on resources.
OTHER CONSESUS SAID.

Is the Bioactivity Means that the Bioactive Compound is

Necessarily"Bio"?

Bioactivity: Positivity and/or Negativity?

The Small Quantity: Does become the Joker?

Essential or
Non-Essential?
But what are?

According to present knowledge, bovine milk,

cheeseand dairy products seem to be by far the
greatestsources of bioactive proteins and peptides
derivedfrom food. Some food proteins cause specific
effects beyond the supply of nutrients, such as IGFs
(insulin-like peptide hormones), lactoferrin,
immunoglobulins and β-lactoglobulin (β-Lg).
The β-Lg is now an important source of bioactive
peptides that, once released, play an important role
in human health, especially against hypertension