• Colombia: Analisys

Market

1
 MARKET ANALISYS | J01C1 - PENICIL.AMPLIO ESPECT.ORL

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
18,339 18,420 271,060
263,646
• Padecimientos dentro de la CT
• Estatus actual de la CT 15,279 231,187
• Futuro de la CT
OTHERS
• Productos en pipeline
30.2%
69.8% 69.4%
PRIV LC 68.8%
PRIV UN 98.2% 98.0%
55.2% LABORATORIOS BAXTER S.A. 97.1%
2.8%
PFIZER S.A.S. 3.2%
TECNOQUIMICAS S.A. 4.2% 30.2% 30.6%
4.4% GOV LC 31.2%
CORPAUL GOV UN
GENOMMA LAB COLOMBIA LTDA. 1.8% 2.0% 2.9%
2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX
-9.2% +8.7% +7.3%
18,007 18,053 183,994 188,106 +14,8% 437,2 82,954
79,652
159,107 366,8 72,079
4,801 5,641 14,842
332,0
4,973
156,334 163,099 372,5
133,095 79,375 82,245
334,8 72,015
13,206 327,5
12,412
9,869

26,012 27,660 25,007 64,8

4,6 31,9 709
64 277
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | J01C1 - PENICIL.AMPLIO ESPECT.ORL
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

+1.8%
+10.7% SULAMP +6.9% BACTESUL
AMOXICILINA CLAVULIN
5,641 163,099 +6,7% SULTAMICILINA SULAMP
CLAVULIN AMOXICILINA 372,5 82,245
156,334 79,375
SULMIC BACMICINE
15.9% 4,973 AMPICILINA + SULBACTAM AMPICILINA + SULBACTAM 327,5 334,8 72,015
4,801 19.3% BACTESUL TACNA
AMPICILINA 133,095 19.1% EUMOXIN
16.1% 21.8% OTHERS OTHERS
13.5% OTHERS 11.2% OTHERS
19.3% 56.4%
13.8% 57,3% 55.8%
14.6% 7.2% 8.7%
15.6% 10.4% 8.4% 55.4%
8.1% 67,0%
8.3% 8.5% 70,6%
22.7% 8.3% 7.6%
8.4% 6.7%
7.7%
14,8% 21.2%
21.3% 23.0%
51.1% 52.7%
52.5% 40.7% 46.5% 55.1% 13,7% 11,5%
11,5%
0,5% 2,6% 10.2% 9.5% 10.6%
9,1% 8,7% 7,9%
5.7% 5.0% 6.4%
8,2% 7,9% 8,5% 7.4% 6.7% 5.5%
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
MEI OTHERS
Brands GOB
ORL 2,3% 11,391,438 TX
51 CIR 3,1% 1,7%
49 Molecules 5,1% 2,5%

246 Specialty No. Physicians

Packs MEG 22,655
PED 3,905
32,8 PED 20,9%
BR 219,9 237,1 220,8 CIR 2,839
BR 27,7 27,7
Government Market Composition ORL 898
Brands 64,5%
MEG GOB 3,429
9 MEI 2,797
10 Molecules GX GX OTHERS 11,610
2,0 2,2 2,5 14,0 8,7 11,0
42 2016 2017 2018 2016 2017 2018
Packs
 MARKET ANALISYS | J01C2 - PENICIL.AMPLIO ESPECT.INY

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
1,702 11,036
SCANDINAVIA PHARMA LTDA. OTHERS
• Padecimientos dentro de la CT PROCAPS S.A. PRIV UN 10.3%
• Estatus actual de la CT GENFAR S.A. 9,586
1.7% 1,382
• Futuro de la CT 4.0% 1,323
8,066
• Productos en pipeline 3.0% 18.1%
20.2%
2.6% 70.7%
PFIZER S.A.S.
19.4% 67.7%
PRIV LC 55.3%
GOV UN 89.7%

81.9% 79.8%
69.4%
LABORATORIOS BAGO S.A. GOV LC 44.7% 32.3% 29.3%

2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX

+23.2% -5.2%
267 +32.2% 7,799 1.526,1 -16,8% 3,603
250
3,237
6,491 3,095
1.132,3
1.056,0
176
4,464
257 7,655 1.458,9 3,309
239 2,719 2,877
6,345
1.067,3 998,2
176
4,464

67,2 65,0 293 376 360

0 10 11 0 146 143 57,8
2016 2017 2018 2016 2017 2018
2016 2017 2018 2016 2017 2018
MARKET ANALISYS | J01C2 - PENICIL.AMPLIO ESPECT.INY
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

PIPERACILINA + TAZOBACTAM
+20.7% MEPRIZINA MEPRIZINA TAPECTAM
257 7,655 PIPERACILINA -6.8%
1.458,9 3,309 PIPERACILINA + TA
239 +31.0% -17,3%
TAPECTAM
PIPERACILINA
DELBACTAM 2,877
6,345 2,719 PIPROCIRA
OTHERS
1.067,3 OTHERS
176 49.8%
998,2
4,464 48.8% 54.5%

94,5%

94,4% 93,7% 25.0%

32.8% 28.2%
11.4%
2,3% 2,5% 3,0% 0.8%
0,1% 0,1% 0,2% 10.2% 13.1%
2,6% 0,6% 2,7% 0,3% 13.0% 1.8% 1.7%
0,1% 6.4%
3,0% 2.4%
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
Brands END
GET
1 3,5% 36,765 TX
MEI 4,5%

8,1%
Packs 4 2 Molecules 2,9 Specialty No. Physicians
2,5
CIR 2839
26,5 29,8
BR 2,3 MEG 22655
49,9% CIR
MEI 2797
Government Market Composition
6,2 GET 626
BR 25,3 5,8 34,0%
Brands GX 4,4 MEG END 349
13 14,6 13,4
GX
0,0
Packs 32 9 2016 2017 2018
2016 2017 2018
Molecules
 MARKET ANALISYS | J01D2 - CEFALOSPORINAS INYECTABL.

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
5,950 6,042 99,966
• Padecimientos dentro de la CT 92,499
• Estatus actual de la CT OTHERS
80,359
• Futuro de la CT 4,661
• Productos en pipeline 22.6%
AMERICAN GENERICS S.A.S.
34.8%

PRIV UN 100.0% 100.0% 99.9%

LABORATORIOS LA SANTE S.A. 6.3% 100.0%
100.0% PRIV LC 100.0%
6.6%
LAFRANCOL S.A.S.

12.2% 17.5%
GOV UN GOV LC
BAYER SCHERING PHARMA A.G. 0.0% 0.0% 0.0% 0.0% 0.1% 0.0%
TECNOQUIMICAS S.A.
2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX
-11.5% +7.3% <% out of 0> <% out of 0>

5,950 6,040 99,897 2,2 69

92,499
1,381 1,493 80,359
4,661

1,525
89,446
82,291
71,582
4,569 4,547
3,135

8,777 10,450 10,208 0,0 0,0 0 0

2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | J01D2 - CEFALOSPORINAS INYECTABL.
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

+5.1% +7.2% <% out of 0> <% out of 0>

TECHNECIUM
MAXIPIME MAXIPIME TECHNECIUM
1,493 1,525 89,446 2,2 69
CEFOPERAZONA CEFOPERAZONA
1,381 82,291
CEFEPIME CEFAZOLINA
CEFTRIAXONA 71,582 CEFEPIME
545 32,849
640 OTHERS 30,043 OTHERS
570
27,622
287 14,170
15,084
285
281 12,512 9,015
221
11,758
212 9,463
193 131 11,004
35 23 10,496
7,941
333 343 23,949
301 14,910
12,502
0,0 0,0 0 0
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
Brands OTHERS
3,705,756 TX
24 9,8%
ORL
6,1%
73 18 Molecules
Packs Specialty No. Physicians
PED
8,3% MEG 22,655
CIR 2,839
59,9 51,3% MEG
53,9 32,3 PED 3,905
BR 51,9
Government Market Composition ORL 898
OTHERS 8,457
24,5%
Packs Brands
1 1 CIR
GX BR
1,9 2,3 3,3 0,0 0,0
2016 2017 2018 2016 2017 2018
1
Molecules
 MARKET ANALISYS | J01G1 - FLUORQUINOLONAS ORALES

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
4,187 130,086 132,052
• Padecimientos dentro de la CT
3,764
• Estatus actual de la CT 3,594 19.1% 114,844
• Futuro de la CT PRIV UN 24.4% 21.9%
• Productos en pipeline OTHERS 56.4%
LABORATORIOS LA SANTE S.A.
34.7% 36.8% PRIV LC 69.6% 55.5%

80.9%
GOV UN 75.6% 78.1%

44.5% 43.6%
6.7% GOV LC 30.4%
7.4%
GENFAR S.A. 7.1% 7.2%
LABORATORIOS SOPHIA S.A. DE C.V.
PISA FARMACEUTICA DE COLOMBIA S.A. PENTACOOP S.A. 2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX

-6.8% -9.4% +9,2% +20.8%

920 90,583 3.387,8 57,634

799 51,064
785 74,418 2.843,5 2.808,2 834,0
63,780 367,1 442,6 39,502

53,374
912 90,156 47,383
776 788 73,649
63,234 2.476,4 2.365,6 2.553,8 36,289

11 3,213 3,681 4,260

8 9 427 546 770
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | J01G1 - FLUORQUINOLONAS ORALES
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

+21.3%
AMBIGRAM
CIPROFLOXACINA PROCATEC NORFLOXACINA
912 -7.0% 90,156 -9.6% LEVOFLOXACINA
CIPRO QUINOPRON 834,0 47,383 53,374 UROFLAV
AVELOX 1,830
CIPROFLOXACINO CIPRO-XR 1,479 NORFLOXACINO
776 788 19,848 +50,7% ADIX
CIMOXEN-XR 73,649 CIPROFLOXACINO ADIX
383 298,5 OTHERS
OTHERS OTHERS 36,289 OTHERS
63,234 16,706 1,588
346 17,725 5,154
390
442,6 42,375
16,297 14,088 164,8 36,287
13,031 0,0
213 367,1 92,8
12,074 0,0
163 9,768 12,427 90,5 59,8 87,0 29,303
129
79 11,186 44,5 70,4 72,6
71 78 9,257
58 45,0
53 55 29,784 3,771
4,636
20,098 19,594 187,1 219,6 211,1 2,491
179 145 137 1,755 869 1,706
2,774 3,151 3,031
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
OTHERS
Brands 11,236,813 TX
28 13,3%

GOB
Packs 71 23 5,0%
Specialty No. Physicians
Molecules
93,4 MEG 22,655.00
MEI 7,3%
BR 98,8 81,4 CIR 2,839.00
107,1 MEI 2,797.00
BR 98,9
Government Market Composition 59,0%
MEG GOB 3,429.00
64,0 15,3% OTHERS 16,619.00
Brands 61,4 72,2 CIR
42
GX 54,4
GX
1,3 1,6 1,7
Packs 79 2016 2017 2018
20 2016 2017 2018
Molecules
 MARKET ANALISYS | J01G2 - FLUORQUINOLONAS INYEC

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
387 12,928
373
• Padecimientos dentro de la CT 356 11,986
• Estatus actual de la CT
10,488
• Futuro de la CT
• Productos en pipeline OTHERS
33.0% LAFRANCOL S.A.S.
37.0% 79.0%
91.6% 81.7%
PRIV UN 98.4% 94.0%
PRIV LC 95.6%

7.7%
TECNOQUIMICAS S.A. 14.6% 21.0%
7.7% GOV UN GOV LC 18.3%
6.0% 8.4% 4.4%
FARMACEUTICA PARAGUAYA S.A. 1.6%
VITALIS S.A. C.I.
2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX
+0.9%
-5.1%
380 10,024 10,211 31,2 +142.1% 2,717
9,794 106
335 342 2,4
+121,2%
2,192
70
21,3
2,0

379 10,009 9,778 10,197 2,611

334 341 28,8
2,121
19,3
6,4 464
1,1 35
5,3 429
1 1 1 15 16 14
2016 2017 2018 2016 2017 2018
2016 2017 2018 2016 2017 2018
MARKET ANALISYS | J01G2 - FLUORQUINOLONAS INYEC
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

+0.9% NIRLIV
-5.1% CIFLOBLAS CIPROFLOXACINA NIRLIV
379 10,009 10,197 2,4 TERMEDOL 106
CIPROFLOXACINO 9,778 CIFLOBLAS +48,1% TERMEDOL
334 341 CIPROFLOXACINA CIPROFLOXACINO
CIPRO CIPRO 2,0
149 +73.8%
3,913 3,615 4,310
138 144 70

90
1,1 2,3
115 3,309 3,263
95 3,367 2,0
98 35
70

1,1
92 76 35
87 2,708 2,725 2,446
16
23 22 15 175
80 74 0,0 0,0 0,0 0 0
2016 2017 2018 2016 2017 2018 2016 2017 2018
2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
Brands OTHERS
1
Molecules 248,705 TX
NML 0,4%
6
0,6%
35,3
44,8 Specialty No. Physicians
27
29,3 29,9 BR 32,5
T/O
0,8% CIR 2,839.00
Packs BR 26,4
MEG 22,655.00
T/O 249.00
Government Market Composition 110,0 4,1% NML 287.00
GX 80,9 90,6 0,8% CIR
Brands MEG OTHERS 13,941.00
2 GX 19,2 19,6 20,3
Packs 4
2016 2017 2018 2016 2017 2018
3
Molecules
 MARKET ANALISYS | J01P2 - PENEMAS Y CARBAPENEMAS

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
8,536 8,639 29,009
• Padecimientos dentro de la CT OTHERS 6.8%
VITALIS S.A. C.I. PRIV UN 7.6%
• Estatus actual de la CT 6.7%
LABORATORIOS SYNTHESIS S.A.S. 23,866
• Futuro de la CT 22,135 34.7%
6,475
• Productos en pipeline 4.9%
PENTACOOP S.A. 2.9% 9.4%
5.5% 41.2%
PRIV LC 41.6%
LABORATORIO PROFESIONAL FARMACEUTICO LAPROFF S.A.
8.7% GOV UN 92.4% 93.2%
57.8% AMERICAN GENERICS S.A.S.
90.6% 65.3%
13.5% GOV LC 58.4% 58.8%
GENFAR S.A.

2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX
+4.6% +1,1%
-5.0%
651 9,833 10,073 7.885,0 8.052,1 +21.1% 18,936
609 9,215 283,5 207,7
587 2,287

5.866,0 14,033
219,4 12,920
2,396
2,851
626 582 9,506 9,758 7.844,4
562 8,942 7.601,6 16,649
5.646,7
11,637
10,069

24 27 25 273 326 316

2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | J01P2 - PENEMAS Y CARBAPENEMAS
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

+4.5% MERONEM
-5.2% TIENAM INVANZ MEROPENEM
626 9,758 283,5 MEROPENEM 2,851 -10.4%
INVANZ 9,506 TIENAM -14,4% MERONEM
582 8,942 PISAPEM
562 TESARE TIESILAN MEROBAC
VILIPEN 2,396
TIESILAN TESARE 2,287 PISAPEM
112,0 219,4 OTHERS
OTHERS OTHERS 207,7 OTHERS
4,929
5,019
4,815
2,008
486 84,4
437 427
121,0 1,738 1,535

157,0
3,899 4,329 120,7
3,631
479
76,2 341 519
121 114 104
85 197 166 206 154 102 72
3 220 202 115
7 8 8 17 6 8 16 8 221 190 172 132
1,9 7,3 5,3 2,7 9,1
2,5
2,3 7,1
1,2 102 56 61 46
2016 2017 2018 2016 2017 2018 2016 2017 2018
2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
URO END
Brands MEG 2,0%
184,205 TX
7 0,0%
12,2%
Packs 11

7 17,3
Specialty No. Physicians
16,3 CIR 2,839.00
Molecules BR 14,3 10,9 11,0 MEI 19,6%
MEI 2,797.00
BR 10,1
Government Market Composition MEG 22,655.00
Brands 65,3% URO 764.00
12,8 CIR
11 GX 11,2 12,3 END 349.00
GX
1,3 2,1 2,1
12 Molecules
41 2016 2017 2018 2016 2017 2018
Packs
 MARKET ANALISYS | J01X1 - ANTIBACTERIANOS GLICOPEP

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
1,157 13,919
• Padecimientos dentro de la CT SCANDINAVIA PHARMA LTDA. OTHERS
LABORATORIOS BUSSIE S.A.
• Estatus actual de la CT
2.4% 4.4% 938 11,109
• Futuro de la CT 884 10,528
LAFRANCOL S.A.S. 2.1% PRIV UN PRIV LC
• Productos en pipeline
13.2%

GOV UN GOV LC

77.8%
SANOFI AVENTIS DE COLOMBIA S.A.

2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR
GX

+14,4% 1.156,9 +15.0% 13,919

202,9
937,7 11,109
884,3 10,528
179,0
163,0
11,395

8,725 9,160
953,9
721,3 758,7

1,803 1,949 2,525

2016 2017 2018 2016 2017 2018

MARKET ANALISYS | J01X1 - ANTIBACTERIANOS GLICOPEP
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

ENTEROCAPS
ENTEROCAPS
+11,6% 202,9 VANBIOTIC +14.3% 11,395 SUMICINA
NIRMET
179,0 VANBIOTIC
VANCOCIN
163,0 9,160 VANCOCIN
SUMICINA 8,725
VANAURUS
VANAURUS
7,412 NIRMET
152,7
129,8 5,644
5,921
135,0

1,818 2,394
16,6 26,0 1,617
4,1 9,8 368
9,3 613 929
0,4 16,7 134 311
14,2 0,0 22,4 0,1 657 28 1,028 37 327 22
0,0 0,5 0,6 6,9 21
2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
2,974.00 TX

Specialty No. Physicians

100,0% MEI 2,797.00
BR 53,5 56,1
51,2
Government Market Composition

Brands
8
GX
Packs 13 2,5 2,6 2,6
2016 2017 2018
MEI
5
Molecules
 MARKET ANALISYS | N02C1 - TRIPTANES ANTIMIGRANOSOS

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
227 2,026
• Padecimientos dentro de la CT 0.5% 5.6%
OTHERS
• Estatus actual de la CT
• Futuro de la CT 12.9% 176
0.5% 1,517
• Productos en pipeline SANOFI AVENTIS DE COLOMBIA S.A. 1,449
6.8% 144 8.2%
PRIV UN 1.1% PRIV LC 27.6%

99.5%
LABORATORIOS ECAR S.A. 10.8% 94.4%
58.6% 99.5%
TECNOFAR TQ S.A.S.GOV UN 98.9% 91.8%
GOV LC 72.4%
11.0%
GLAXOSMITHKLINE COLOMBIA S.A.

2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX

2 418 225,8 1,913

-17.0% +25,8% +31.9%
43,0
-48.0% 175,6
1 1,330
142,7 30,8
1,244
1,099
1 26,6
835
182,8 702
119 113 144,8
116,1
669
397 496

2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | N02C1 - TRIPTANES ANTIMIGRANOSOS
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

SUMATRIPTAN
RELPAX RELPAX SUMATRIPTAN
2 418 43,0 SITRAN 1,244 SITRAN
-17.0% +27,1% SUAXINA
+33.1% IMIGRAN
IMIGRAN
SUAXINA
-48.0% NARAMIG
30,8 NARAMIG
1 835
24,9
26,6
702
1 14,4 1,067
11,1
625
497
119 113 8,0
8,0 9,1
0,0 1,0 6,0
90 107 90
7,0 6,0
3,8 104 10 88 7 50 5
0,6 0,4 0,2 1 8 33
2016 2017 2018 2016 2017 2018 2016 2017 2018
2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
T/O
Brands
0,4%
191,734 TX
1 NEU
Packs 2
22,7%

Specialty No. Physicians

2
MEG 22,655.00
Molecules
28,9
MEI 2,797.00
BR 260,9 BR 26,4 27,1 53,9% MEG NEU 1,011.00
Government Market Composition T/O 1,522.00
147,6 23,0%
Brands 102,3 MEI
7
GX 3,4 3,4 3,7
Packs 11
2016 2017 2018 2016 2017 2018
3
Molecules
 MARKET ANALISYS | J02A0 - ANTIMICOTICOS SISTEMIC

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
5,276 79,406
• Padecimientos dentro de la CT
GENFAR S.A. 4,632
• Estatus actual de la CT
• Futuro de la CT 16.6% 4,068 35.9% 62,708
59,277
• Productos en pipeline OTHERS
32.3% 72.4%
PRIV UN 56.9%
45.9%

15.3% PISA FARMACEUTICA DE COLOMBIA S.A. 77.2%

PRIV LC 79.5%

64.1%
6.4% 54.1%
TECNOQUIMICAS S.A.
13.1% GOV UN 43.1%
6.6% 27.6%
LABORATORIO PROFESIONAL FARMACEUTICO LAPROFF S.A. GOV LC 20.5% 22.8%
PENTACOOP S.A.
9.7%
B. BRAUN MELSUNGEN A.G. 2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX

+10.4%
2,636 -15.2% 57,470 3.379,9 21,936
+30,1% +34.4%
47,136 48,421
951 1.432,3
1,869 1,896
2.199,7 14,287
564 1.995,7
512,4 12,141 18,700
768 50,395 277,1
40,676 42,441
11,574
1,685 9,494
1.947,6
1,332 1.718,6 1.687,2
1,101

6,460 5,980 7,075 2,646 2,713 3,237

2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | J02A0 - ANTIMICOTICOS SISTEMIC
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

VORICOX
FLUCONAZOL FLUCONAZOL VORICOX
951 +11.3% 50,395 1.432,3 ITRACONAZOL 18,700
ECALTA DIFLUCAN ITRACONAZOL
-23.0% KETOCONAZOL
DIFLUCAN BATEN +40.3% VFEND
42,441 KETIMIC
768 FUNEX 40,676 FUNEX VICONAZOL
+127,3% OTHERS 7,110
OTHERS OTHERS OTHERS
555 856,8
33,761 11,574
564
23,650 26,637
496 9,494 2,598 3,293
826
313 1,793
79 512,4 2,872 2,237
186,7 506 0
37 3,878 159,3 631
58 4,437 4,417 52 1,636
55 54
40 4,347 2,398 277,1 167,9
38 2,335 170,5
49 2,533 2,282 2,243 32,7 6,369
37 113,2 5,422
221 87,1 4,424
129 122 6,268 6,751 7,576 63,8 0,0 117,0
67,5 13,6 133,8
52,0
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
CIR OTHERS
Brands
3,8%
1,886,988 TX
DER
29 0,0%
10,5%

Packs 82 28
Molecules Specialty No. Physicians
MEG 22,655.00
GOB 3,429.00
89,4 BR 34,3 46,3% MEG DER 1,260.00
Government Market Composition CIR 2,839.00
55,3 22,6
31,1% OTHERS 13,421.00
Brands BR 42,8 GOB
13,1
19
GX GX
3,8 5,4 5,3 1,5 1,6 1,7
Packs 56 20
Molecules 2016 2017 2018 2016 2017 2018
 MARKET ANALISYS | N03A0 - ANTIEPILEPTICOS

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
32,359 350,310
• Padecimientos dentro de la CT
LABORATORIOS LA SANTE S.A.
• Estatus actual de la CT 27,992
26,349 26.7%
• Futuro de la CT 16.0% PRIV UN 35.1% 278,295 279,057
• Productos en pipeline
44.6% 39.5% PRIV LC 32.0% 33.4%

14.4% FARMALOGICA S.A.

OTHERS 50.3%
73.3%
GOV UN 64.9%
60.5% GOV LC 68.0% 66.6%
11.6% 55.4%
GENFAR S.A.
7.7%
MERCK COLOMBIA S.A. 2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX
-4.3% +2.5%

12,492 93,087 93,661 21.001,5 -12,9% +16.5% 256,649

89,132
11,357
3,419 10,405
6.435,0
15.500,5 15.943,4 189,163
3,351 185,970
3,435
69,127 67,540
68,091 6.117,8 8.041,4 211,162

152,892 145,854
9,073 14.566,5
8,007
6,971
9.382,7
7.902,0
21,041 23,960 26,121
36,271 40,116 45,487

2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | N03A0 - ANTIEPILEPTICOS
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS

+1.2% -0.4%
DOLICA
FENOBARBITAL CARBAMAZEPINA PRELUDYO
3,419 3,435 68,091 69,127 +11,8% 8.041,4 PREGABALINA 211,162
3,351 CARBAMAZEPINA 67,540 ATEMPERATOR +17.5% PREGABALINA
LYRICA
KAPTIN DEPAKENE TOPIRAMATO
737 723 1.870,9 NEUPREL 55,301
943 ATEMPERATOR AVALPRIC TOPICTAL
26,734 6.435,0 OTHERS
OTHERS 27,274 26,344 OTHERS 6.117,8 OTHERS
859,3 152,892
145,854
804 1.646,1 1.672,6
892 699 45,333 48,155
1.947,7 45,552
11,574 13,271 14,235
521 1.319,8
575 612 1.873,3 35,889 38,636
3,181 743,2 28,242
203 2,620 5,308 4,382 0,4
185 208 3,836 3,791 1.109,5 17,030
915,6 23,482 21,651
7,336
1,168 23,443 2.884,4 111,8 13,074
962 971 19,978 18,789 2.068,7
1.571,0 47,304 47,420
35,505

2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
Brands OTHERS
MEI
0,0%
5,387,894 TX
37 11,4%
27 Molecules Specialty No. Physicians
153 MEG 22,655.00
Packs NEU PSI 1,438.00
13,5%
38,2% MEG
19,7 26,3 NEU 1,011.00
BR 20,3 20,2
23,8 MEI 2,797.00
BR 23,8
Government Market Composition OTHERS 21,589.00

Brands
Packs 56 46 GX 3,7 GX 5,8 21,8%
2,6 2,6 2,5 4,3
2016 2017 2018 2016 2017 2018 PSI

35
Molecules
 MARKET ANALISYS | N05A1 - ANTIPSICOTICOS ATIPICOS

Market Description Top Corporations Retail Market (Units MAT) Market Composition UN (‘000 MAT) Market Composition LC (‘000 000 MAT)
Medical Highlights %MS PRIV & GOV PRIV & GOV
10,016 194,341
• Padecimientos dentro de la CT
PRIV UN 11.1%
• Estatus actual de la CT 8,758 8,701 166,195
• Futuro de la CT 12.4% 11.9% 147,839
• Productos en pipeline
OTHERS
35.8% 71.4%
ROPSOHN THERAPEUTICS LTDA.
42.5% 71.9%
PRIV LC 72.0%
GOV UN 88.9%
87.6% 88.1%

5.5% 28.6%
GOV LC 28.0% 28.1%
LABORATORIOS LA SANTE S.A. 5.9% 10.3%
SANOFI AVENTIS DE COLOMBIA S.A. LABORATORIO PROFESIONAL FARMACEUTICO LAPROFF S.A.
2016 2017 2018 2016 2017 2018

Retail Market UN (’000 MAT) Retail Market LC (‘000 000 MAT) Government Market UN (‘000 MAT) Government Market LC (‘000 000 MAT)
BR & GX BR & GX BR & GX BR & GX
BR BR
GX GX
-3.3%
-7,2%
1,110 +14.1% 138,704 8.906,3 +15.9% 55,637
1,087
1,037
119,536 7.671,0 7.663,6 46,659
106,450 41,389
605 571
690 6.676,0
131,224 5.824,2 5.948,3 49,364
112,762 40,567
35,358
103,690

505 516
347 2.230,3 1.846,7 1.715,3
6,774 7,480 6,030 6,092 6,273
2,760
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018
MARKET ANALISYS | N05A1 - ANTIPSICOTICOS ATIPICOS
Top Brands Retail UN (‘000 MAT) Top Brands Retail Values (‘000 000 MAT) Top Molecules Gov UN (‘000 MAT) Top Molecules Gov Values (‘000 000 MAT)
Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS Total Market Size & %MS
-5,6%
RISDONA
CLOZAPINA SOCIAN 5.824,2 RISDONA
+6.8% +12.5% INVEGA
690 131,224 6.676,0 49,364
SOCIAN CLOZAPINA 4.152,6 +18.2% RISPERIDONA
149,1 RISOFREN
605 DENIBAN SAPHRIS 5.948,3 INVEGA
112,762 150,0 TRACTAL
571 SAPHRIS TANYL 40,567 QUETIAPINA
103,690 OTHERS 19,053
OTHERS OTHERS 35,358 OTHERS
198
409
4.873,1 17,164
317 3.920,0
120,125 15,023 6,376
134
104,487 1,481 4,444
96,775 2,163
1,438 0
47 4,775 3,707
4,320
33 140
131
675,5 816,7
617,9
193 58 74 1,993 2,406 3,349 178,1 24,6 206,7
179,9 14,577 14,984 15,784
24 30 452 835 1,042
5,449 924,6 754,6 825,1
41 38 2,785 1,686 3,970 1,064 1,259
2016 2017 2018 2016 2017 2018 2016 2017 2018 2016 2017 2018

Retail Market Composition Price Evolution Retail Market (’000 MAT) Price Evolution Gov Market (’000 MAT) Specialties Composition (TX)
BR vs GX BR vs GX Retail Market MAT 18
MEI OTHERS
Brands NEU
1,7%
1,027,412 TX
14 6,2% 0,0%

MEG
Packs 40 17 14,4% Specialty No. Physicians
Molecules PSI 1,438.00
8,3 MEG 22,655.00
190,1 7,0 NEU 1,011.00
197,6
BR 171,3 BR 5,3 MEI 2,797.00
Government Market Composition
Brands OTHERS 10,117.00
36 3,7 74,1%
GX 2,7 3,3
38 Molecules GX
13,1 21,6 PSI
5,5
2016 2017 2018
174 2016 2017 2018
Packs