Scribd Logo
Upload

Welcome to Scribd!

  • EANO Guidelines For The Diagnosis and Treatment of Meningiomas

    Uploaded by

    David Wyanto
    9 views16 pages
    The guidelines provide recommendations for the diagnosis and treatment of meningiomas of WHO grades I-III. Key points include: - The majority of meningiomas are WHO grade I, while grades II and III are less common. - Diagnosis is typically made using MRI or CT scans to identify a solid, rounded mass attached to the dura with contrast enhancement and dural tail. - Treatment recommendations include surgical resection with the goal of Simpson grade I or II. Radiation therapy is recommended for higher grades or residual tumor. - Recurrence rates are 20-30% at 10 years for grade I after total resection, increasing to 50% for subtotal resection, and 30-40

    Original Description:

    jurnal onko meningioma

    Original Title

    jurnal onko

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The guidelines provide recommendations for the diagnosis and treatment of meningiomas of WHO grades I-III. Key points include: - The majority of meningiomas are WHO grade I, while grades II and III are less common. - Diagnosis is typically made using MRI or CT scans to identify a solid, rounded mass attached to the dura with contrast enhancement and dural tail. - Treatment recommendations include surgical resection with the goal of Simpson grade I or II. Radiation therapy is recommended for higher grades or residual tumor. - Recurrence rates are 20-30% at 10 years for grade I after total resection, increasing to 50% for subtotal resection, and 30-40

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    9 views16 pages

    EANO Guidelines For The Diagnosis and Treatment of Meningiomas

    Uploaded by

    David Wyanto
    The guidelines provide recommendations for the diagnosis and treatment of meningiomas of WHO grades I-III. Key points include: - The majority of meningiomas are WHO grade I, while grades II and III are less common. - Diagnosis is typically made using MRI or CT scans to identify a solid, rounded mass attached to the dura with contrast enhancement and dural tail. - Treatment recommendations include surgical resection with the goal of Simpson grade I or II. Radiation therapy is recommended for higher grades or residual tumor. - Recurrence rates are 20-30% at 10 years for grade I after total resection, increasing to 50% for subtotal resection, and 30-40

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 16

    EANO Guidelines For The

    Diagnosis and Treatment of


    Meningiomas
    Goldbrunner R, Minniti G, Preusser M, Jenkinson M,
    Sallabanda K, Houdart E, Deimling A, Stavrinou P, Lefranc F,
    Lund-Johansen M, Moyal E, Brandsma D, Henriksson R,
    Soffietti A, Weller M
    Journal : Lancet Oncol 2016; 17: e383–91

    Pembimbing :
    Dr. Theresia Runtuwene, Sp.S (K)
    Dr. Rizal Tumewah, Sp.S (K)
    Pendahuluan

     Meningioma  tumor primer intrakranial terbanyak


     Mayoritas  WHO grade I
     Minoritas  WHO grade II dan III
     Tatalaksana meningioma terlihat memiliki standar, namun :
     Uji klinis terkontrol  belum ada
     Tatalaksana berdasarkan pengalaman klinis
    WHO 2016 Grading for Meningiomas
    Diagnosis
     MRI atau CT Brain
     Massa solid berbentuk bulat
     Menempel duramater
     Menyengat dengan pemberian kontras
     Dural tail
     CT Brain  deteksi kalsifikasi
     Angiografi konvensional jarang dilakukan, hanya pada kasus
    tertentu (petroclival meningioma)
     PET tracer  Ga-Dotatate atau Y-Dotatate untuk menunjukkan
    ekspresi dari somatostatin receptor 2
    Recommendations for the therapeutic
    management of meningiomas of WHO grades I–III
    Recommendations for the therapeutic
    management of meningiomas of WHO grades I–III
    Simpson grades of resection and corresponding
    EORTC/RTOG definitions of extent of resection
    Mutasi Pada Meningioma
    Terapi
    Terapi Farmakologi

     Hydroxycarbamide  Imatinib
     Cyclophosphamide–
    doxorubicin–vincristine  Erlotinib
    chemotherapy  Gefitinib
     Interferon-alfa  Vatalanib
     Megestrol acetate
     Sunitinib
     Medroxyprogesterone
    acetate  Bevacizumab
     Octreotide  Trabectedin
     Pasireotide (long-acting  Tetrahydroisoquinoline
    release)
    Key Recommendations for The
    Management of Meningiomas
    Key Recommendations for The
    Management of Meningiomas
    Key Recommendations for The
    Management of Meningiomas
    Key Recommendations for The
    Management of Meningiomas
    Prognosis

    WHO Grade 1 WHO Grade 2 WHO Grade 3

    10 year recurrence (total 5 year recurrence (total 5 year progression-free


    ressection)  20-30% ressection)  30%  12%-57%

    10 year recurrence 5 year recurrence (total


    (subtotal ressection)  ressection)  40%
    50%
    TERIMA KASIH

    You might also like