HEMATOPOIESIS

RINNY ARDINA, S.ST., M.Si

• Hematopoiesis is defined as the production, development,
differentiation, and maturation of all blood cells.

• Bone marrow is able to produce 3 billion red cells, 1.5 billion

white cells, and 2.5 billion platelets per day per body weight.

• Within the basic bone marrow structure lies the mechanism

to:
1. Constantly supply the peripheral circulation with mature
cells.
2. Mobilize the bone marrow to increase production if
hematological conditions warrant.
3. Compensate for decreased hematopoiesis in bone marrow
by providing for hematopoietic sites outside of the bone
marrow (non-bone marrow sites, the liver and spleen).
• 2 minggu-2 bulan pada masa fetal/fetus 
eritropoiesis terjadi di yolk sac  produksi Hb
Gower I, Gower II, dan Portland
• 2-7 bulan masa fetal/fetus  hati dan limpa
mengambil alih proses hematopoiesis, sel leukosit
dan megakariosit mulai diproduksi dgn jumlah
sedikit
• Dari 7 bulan sampai kelahiran  sumsum tulang
mengambil peran utama hematopoiesis  berlanjut
ke kehidupan dewasa  Hb A mulai terbentuk
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TERIMA KASIH