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  • K19. Pruritus

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    Orient Darirohman
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    1) Pruritus, or itching, is caused by activation of free nerve endings in the dermo-epidermal junction, which leads to sensations that are transmitted along neuronal pathways to the brain. 2) Pruritus can be classified as either acute (<1 month) or chronic (>1 month) and can have various underlying causes including skin conditions, systemic diseases, neuropathies, and psychological factors. 3) Mediators of pruritus include neurotransmitters, inflammatory cytokines, and other substances that activate cutaneous C nerve fibers to induce itching sensations.

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    1) Pruritus, or itching, is caused by activation of free nerve endings in the dermo-epidermal junction, which leads to sensations that are transmitted along neuronal pathways to the brain. 2) Pruritus can be classified as either acute (<1 month) or chronic (>1 month) and can have various underlying causes including skin conditions, systemic diseases, neuropathies, and psychological factors. 3) Mediators of pruritus include neurotransmitters, inflammatory cytokines, and other substances that activate cutaneous C nerve fibers to induce itching sensations.

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    6 views14 pages

    K19. Pruritus

    Uploaded by

    Orient Darirohman
    1) Pruritus, or itching, is caused by activation of free nerve endings in the dermo-epidermal junction, which leads to sensations that are transmitted along neuronal pathways to the brain. 2) Pruritus can be classified as either acute (<1 month) or chronic (>1 month) and can have various underlying causes including skin conditions, systemic diseases, neuropathies, and psychological factors. 3) Mediators of pruritus include neurotransmitters, inflammatory cytokines, and other substances that activate cutaneous C nerve fibers to induce itching sensations.

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    of 14

    dr AMBAR RIALITA SpKK

    gejala kelainan kulit menyebabkan


    rangsangan untuk menggaruk

    KLASIFIKASI :
    A. Waktu
    - Pruritus Akut
    beberapa hari
    insect bite reaction
    - Pruritus Kronik
    berbulan-bulan
    Gatal merupakan akibat aktivasi ujung bebas
    saraf pada dermo epidermal junction

    Reseptor  neuron primer  neuron


    sekunder di radik dorsalis medula spinalis
     neurit menuju kontra lateral melalui
    traktus spino talamus neuron tertier  tr
    talamokortikal  kortek serebri
     Nervus intraepidermal ----- neuropeptida
     Keratinosit : mediator neural dan reseptor
     Adenosine triphosphat channel dan
    adenosine receptor
    = C nerve fiber
    B. Manifestasi klinik

    - Kelainan kulit
    - Penyakit Sistemik
    - Neuropati
    - Psikogenik
     Scratch ---------------- epidermal barier
    | |
    | |
    Itch |
    | |
    | |
    C nerve ------------- Neuropeptide,
    tryptase
    Fiber inflammatory mediators
    A. Mediator Sentral
    - Opioid peptida
    - Neurotropin
    B. Mediator Perifer
    - Histamin, Proteinase, Substance P
    - Interleukin
    - Prostaglandin
    - Dermatitis Atopik
    - Dermatitis Kontak
    - Dermatitis Seboroik
    - Urtikaria
    - Scabies
    - Fungal infections
    - Psoriasis
    - Penyakit ginjal kronik
    - Cholestasis
    - Penyakit Endokrin
    - Kelainan Hematologi
    - HIV disease
     Kadar uremia meningkat --- kalsium
    meningkat ---- pruritogenik sitokin -----
     Merusak C nerve fiber
     gangguan proliferasi sensory nerve ending
    ------- aktivitas sel mast meningkat
    ------- histamin meningkat
    TOPIKAL
    - Asam salisilat
    - Imunomodulator
    - Coolant & counter irritants
    - Antihistamin
    - Barrier repair
     SISTEMIK
    - Antihistamin
    - Opiate antagonis
    - Antidepresan
    - Gabapentin

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