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Leprosy
Leprosy
MICHAELLA E. BUSTILLOS
•Hansen’s disease
•A chronic systemic infection
characterized by progressive
cutaneous lesions.
ETIOLOGY
• Causal organism is Mycobacterium leprae
• It resembles the Tubercle bacillus
• Leprosy bacilli may be found by making acid-
fast stains of materials from lesions of the
skin and lymph nodes.
•LESIONS are the
sources of infection
MODE OF TRANSMISSION
• Exact MOT is unknown, but probably enter the
body through the skin or mucous membrane
• Can be transmitted through respiratory droplets
• Cats and dogs may play a part in the transfer of
the disease
TYPES
• LEPROMATOUS
- Formation of nodules in the skin and mucous
membrane
• TUBERCULOID
- formation of patches on the surface of the body and by
nerve lesions.
• BORDERLINE (Dimorphous) Leprosy
- has the characteristics of both lepromatous and
tuberculoid. Skin lesions of this type are diffused and poorly
defined.
PATHOLOGY
• Mycobacterium leprae attacks the peripheral
nerves, especially the ulnar, radial, posterior-
popliteal, anterior-tibial and facial nerves.
• When the bacilli damage the skin’s fine nerves,
they cause anesthesia, anhidrosis, and dryness.
• If they did attack a large nerve trunk, motor nerve
damage, weakness and pain occur, followed by
peripheral anesthesia, muscle paralysis and
atrophy.
•Incubation period is prolonged
and undetermined, probably from
a few months to 25 years.
•Average is 2-3 years.
•Ranges from five and a half
months to eight years.
COURSE OF THE DISEASE
1. LEPROMATOUS LEPROSY
• Nodules appear in crops on the skin, usually on the hands,
feet, and face.
• Gradually skin thickens, eyebrows disappear, some of the
nodules ulcerate, while others are absorbed.
• This type of leprosy produces a peculiar thickening of the
skin on the forehead and cheeks, becoming a lion like
appearance.
• Patient may live ten or twenty years.
2. TUBERCULOID LEPROSY
• Have no prodromal symptoms except neuritis.
• Trophic ulcers appear on the feet and hands, fingers and
toes undergo total atrophy, and blisters appear on the
trunk.
• Final stage is accompanied by facial paralysis and
gangrene of the feet.
• Patient may live for thirty or forty years.
COMPLICATIONS
• Hemorrhage • Neuritis
• Pneumonia • Mutilation of the
• Tuberculosis features and the
• Gangrene limbs.
• Aphonia • Blindness
DIFFERENTIAL DIAGNOSIS
• HISTAMINE TEST is used to differentiate tuberculoid
leprae from syringomyelia and other diseases.
• Diagnosis is made by smears from the mucous
membranes and by making sections of suspected
lesions.
• Tissue biopsy
• Blood tests show increased RBC & ESR; decreased
serum calcium, albumin and cholesterol levels.
PERIOD OF COMMUNICABILITY