HIPERSENSITIVIT Evi Puspia

AS TIPE 1 Sari
 TYPE I HYPERSENSITIVITY
IgE-mediated reactions
Commonly called allergic reactions or allergy
 are stimulated by the binding of IgE, via its Fc
region, to high-affinity IgE-specific Fc receptors
designated FcεRI. FcεRI are expressed on mast
cells, basophils, and eosinophils.
Type I hypersensitivity reactions are rapid,
occurring within minutes after challenge
(reexposure to antigen). Consequently, allergic
reactions are also called immediate
hypersensitivity
TIPE 1 HYPERSENSITIVITY
REACTIONS
When the IgE molecules encounter antigens, a
cascade of events leads to destabilization and
release of inflammatory mediators and cytokines
from mast cells and basophils. This ultimately results
in the clinical manifestations of type I
hypersensitivity, which include rhinitis, asthma, and,
in severe cases are anaphylaxis
Tipe 1 hypersensitivity reactions
PHASE ALLERGIC
REACTIONS
the development of allergic reactions can be
divided into 3 phases:
(1)The sensitization phase, during which IgE
antibody is produced in response to an antigenic
stimulus and binds to specific receptors on mast
cells and basophils;
(2)the activation phase, during which reexposure
(challenge) to antigen triggers the mast cells and
basophils to respond by release of the contents of
their granules; and
(3)The effector phase, during which a complex
response occurs as a result of the effects of the
many inflammatory mediators released by the mast
cells and basophils. As noted above, the clinical
TIPE 1 HYPERSENSITIVITY
MECANISMS
CLINICAL MANIFESTATIONS OF TIPE
1 HYPERSENSITIVITY

Clinical manifestations of allergic reactions include

localized reactions such as allergic rhinitis, atopic
dermatitis, food allergies, and obstructive pulmonary
diseases such as asthma, bronchitis, and emphysema.
Systemic reactions can lead to life-threatening
anaphylaxis.
Despite the dangerous systematic reactions produced
by type I hypersensitivity reactions mediated by IgE,
the value of this immunoglobulin probably lies in its
ability to combat parasitic infections