Development of the central

nervous system

Sanjaya Adikari
Department of Anatomy
Neural tube
& cavity
Development of brain
Prosencephalon 1a
1 (forebrain)
1b
Mesencephalon
2 (midbrain) 2

3 Rhombencephalon 3a
(hindbrain)
3b
 Telencephalon Cerebral hemispheres
1a

1b Diencephalon Thalamus, hypothalamus

subthalamus, epithalamus
2
tectum, tegmentum and
3a Midbrain cerebral pedunculi

3b
pons, upper medulla
Metencephalon and cerebellum

Myelencephalon lower medulla

Lateral ventricle
Foramen of Monro

3rd ventricle
Aqueduct

4th ventricle

Central canal of SC
Development of spinal cord and
brain stem

Mantle layer

Marginal layer

Neuroepithelial layer
 1 Neuroblast cells
Neurons

Neuroepithelial cells

2 Gliablast cells
Glial cells

Ependymal cells Oligodendroglia Astroglia Microglia

 Alar plate (sensory)
Mantle layer

Marginal layer

Sulcus limitans

Neuroepithelial layer Basal plate (motor)

 Sensory

Motor

Posterior horn

Lateral horn
Sensory

Motor
Anterior horn
 GSA
BA
VA
VE
BE
SE