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    Opioid induced hyperalgesia (OIH) occurs when increased opioid use leads to an increased pain response, working through NMDA receptors and calcium influx that increase sensitization. The student researched OIH through scholarly articles and site visits, building skills in areas like reading, writing, organization, time management, and developing a passion for the topic. Future goals are to find an advisor, compare molecular theories of OIH, and identify more concrete ways for doctors to diagnose OIH.

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    Opioid induced hyperalgesia (OIH) occurs when increased opioid use leads to an increased pain response, working through NMDA receptors and calcium influx that increase sensitization. The student researched OIH through scholarly articles and site visits, building skills in areas like reading, writing, organization, time management, and developing a passion for the topic. Future goals are to find an advisor, compare molecular theories of OIH, and identify more concrete ways for doctors to diagnose OIH.

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    46 views9 pages

    Foyez

    Uploaded by

    api-461128448
    Opioid induced hyperalgesia (OIH) occurs when increased opioid use leads to an increased pain response, working through NMDA receptors and calcium influx that increase sensitization. The student researched OIH through scholarly articles and site visits, building skills in areas like reading, writing, organization, time management, and developing a passion for the topic. Future goals are to find an advisor, compare molecular theories of OIH, and identify more concrete ways for doctors to diagnose OIH.

    Copyright:

    © All Rights Reserved
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    of 9

    What if medicine made you

    worse instead of better?


    Maisha Foyez
    IR II
    River Hill High School

    Molecular Mechanisms of Opioid


    Induced Hyperalgesia and Clinical
    Approach to Diagnosis
    Introduction
    ● Overview
    ○ Background
    ○ Current Research
    ○ Future Goals
    ○ Independent Research Course
    Overuse and Misuse

    Medical, Social, Economic


    Consequences

    Overdose Deaths
    What is Opioid Induced Hyperalgesia?
    ● Increased opioids use → increased pain response to other painful stimuli
    ● How does it work?

    N-Methyl-d-Aspartate Increased
    Influx of Calcium
    Receptor Sensitization
    Research Process
    Scholarly Articles
    Information
    Scholarly Articles Site Visits Advisor Requests
    Requests

    Finding accurate Researching in a Building


    Professionalism
    sources college setting Relationships
    Skills Gained from IR

    Reading/Writing
    Organization
    Skills

    Time Management Passion/Interest


    Future Goals
    ● Find advisor
    ● Compare validity of different molecular theories
    ● Find a more concrete way for physicians to identify OIH

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