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  • Steroids: Presented By, Aksa Simon Vicky Mary Johnson

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    aksa simon
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    This document discusses the major classes of steroid hormones including corticosteroids like cortisol and mineralocorticoids like aldosterone, as well as sex steroids like progesterone, testosterone, and estradiol. It describes the biosynthesis of steroid hormones and the relative activity of systemic corticosteroids. In particular, it examines glucocorticoids like cortisol, their actions in various body systems, potential adverse drug reactions, and indications and contraindications for their use.

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    it is about steoids, its classification and indications

    Original Title

    STEROIDS

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    This document discusses the major classes of steroid hormones including corticosteroids like cortisol and mineralocorticoids like aldosterone, as well as sex steroids like progesterone, testosterone, and estradiol. It describes the biosynthesis of steroid hormones and the relative activity of systemic corticosteroids. In particular, it examines glucocorticoids like cortisol, their actions in various body systems, potential adverse drug reactions, and indications and contraindications for their use.

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    © All Rights Reserved
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    9 views11 pages

    Steroids: Presented By, Aksa Simon Vicky Mary Johnson

    Uploaded by

    aksa simon
    This document discusses the major classes of steroid hormones including corticosteroids like cortisol and mineralocorticoids like aldosterone, as well as sex steroids like progesterone, testosterone, and estradiol. It describes the biosynthesis of steroid hormones and the relative activity of systemic corticosteroids. In particular, it examines glucocorticoids like cortisol, their actions in various body systems, potential adverse drug reactions, and indications and contraindications for their use.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 11

    STEROIDS

    PRESENTED BY,
    AKSA SIMON
    VICKY MARY JOHNSON
    MAJOR CLASSES OF STEROID HORMONES

    1. Corticosteroids
    • Glucocorticoids (Cortisol)
    • Mineralocorticoids (Aldosterones)
    1. Sex steroids
    • Progestogens (Progesterone)
    • Androgens (Testosterone)
    • Estrogens (Estradiol)
    BIOSYNTHESIS
    RELATIVE ACTIVITY OF SYSTEMIC
    CORTICOSTEROIDS
    GLUCOCORTICOIDS

    • Binds to glucocorticoid receptors


    • Effective in fight inflammation caused by
    immune system disorders
    ACTIONS
    • Carbohydrate, protein, fat & calcium metabolism
    • Water excretion
    • CVS, CNS
    • Inflammatory responses
    • Immunological and allergic responses
    • Skeletal muscles
    ADVERSE DRUG REACTIONS
    • Hyperglycemia
    • Cushing’s habitus
    • Osteoporosis
    • Peptic ulceration
    • Suceptability to infection
    • Muscular weakness
    • Feotal abnormalities & growth retardation
    MINERALOCORTICOIDS
    • Enhancement of sodium reabsorption in DCT
    • Associated with rise in potassium and
    hydrogen ions excretion
    ADVERSE DRUG REACTION
    • Sodium and water retention
    • Hypertension
    • Edema
    • Hypokalaemic alkalosis
    INDICATIONS
    o Replacement therapy
    o Pharmacotherapy
    • Arthritides
    • Autoimmune disease
    • Bronchial asthma
    • Severe allergic reactions
    • Collagen disease
    • Malignancies
    • Organ transplantation
    CONTRAINDICATIONS
    • Peptic ulcer
    • Diabetic mellitus
    • Hypertension
    • Osteoporosis
    • CHF
    • Renal failure

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