Similar results were shown
in the rats dosed with
99mTc-DTPA solution
(positive control), indicating
that all 99mTc-labeled beads
reached the stomach after
administration
In addition, more small
beads remained in the
stomach throughout the 4
hour study period, compared
with the medium).
1 GAMACHU D.(B.PHARM) AAU
Since a size 9 gelatin mini capsule was used
as a carrier to deliver the beads into the rats,
the rapidly dissolved gelatin capsule was
sometimes observed to stick onto the
esophagus shortly after dosing, as shown in
the appropriate scintiscans (M).
The scintigraphy images indicated that one
or two (of the total three beads loaded per
capsule) of the large beads (2–3micrometer)
remained in the stomach throughout the 4
hour scanning period (Figure 3P), which
was further validated by CPM quantification
at each section along the GI tract.
From the scintiscans, both small (0.5–1mm)
and medium (2-3mm) beads were able to
empty from the stomach intact; however,
although not significantly different, the
gastric emptying time of the small beads
tended to be longer than the medium beads
For those rats dosed with beads sized 2–
3micrometer, the CPM at the stomach was
significantly higher, compared with those
rats dosed with the other two larger sized
PMMA beads (p<0.05).
This indicated that beads of 2–3micrometer
stayed in the stomach significantly longer
than beads of<2micrometer, and were not
able to pass through the rat pylorus intact
for at least 4 hours.
09/02/2020
In rat more small beads
remained in the stomach
throughout the 4 hour
study period, compared
with the medium