SEPSIS

SURGERY TUTORIAL
 DEFINE SEPSIS AND SEPTIC SHOCK

• SEPSIS- IS A LIFE THREATENING ORGAN DYSFUNCTION CAUSED BY DYSREGULATED HOST RESPONSE TO

INFECTION.

• SEPTIC SHOCK –DEFINED BY PERSISTING HYPOTENSION REQUIRING VASOPRESSORS TO MAINTAIN A

MAP> 65 MMHG AND A SERUM LACTATE LEVEL GREATER THAN 2 MMOL/L (18 MG/ DL) DESPITE
ADEQUATE FLUID RESUSCITATION.
 PATHOPHYSIOLOGY OF SEPSIS

• • PRIMARY BLOODSTREAM INFECTION OR SECONDARY BACTEREMIA → LOCAL IMMUNE

RESPONSE → IMMUNE CELLS RELEASE PRO-INFLAMMATORY CYTOKINES → IMMUNE
RESPONSE SPREADS BEYOND LOCAL ENVIRONMENT →UNREGULATED, EXAGGERATED
SYSTEMIC IMMUNE RESPONSE → VASODILATION AND HYPOTENSION → INVOLVEMENT OF
TISSUES REMOTE FROM THE SITE OF INJURY/INFECTION RESULTING IN MULTIPLE MAJOR
ORGAN DYSFUNCTION →PERIODIC IMMUNOPARALYSIS
DEFINE QSOFA SCORE IN MANAGEMENT OF SEPSIS
MANAGEMENT