Preparation and Characterization of Magnetite/PEG Nanoparticles

Combined with Curcumin for Drug Delivery System

Ahmad Taufiq1*, Kusnunnahari1, Rosy Eko Saputro1, Nandang Mufti1,

Sunaryono1, Arif Hidayat1

Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri

1

Malang, Jl. Semarang 5 Malang 65145, Indonesia

Corresponding author : ahmad.taufiq.fmipa@um.ac.id

International Conference on Life Sciences and Technology

ICOLIST 2019 September, 12 – 13 2019
 OUTLINES
1 Background

2 Experimental Method

3 Results & Discussion

4
Conclusion 2
 DOX is therapeutic anticancer drug.
But toxic and have bad side effects
for normal body tissue

Recent Problem
Novelty
Updates Statements
Around 18.1
million new Drug Delivery System
cancers were with
diagnosed and Fe3O4/PEG/Curcumin
9.6 million nanoparticle
people died in
2018. The
conventional
treatment such
as surgery and
radiating still
have serious
impact
Experimental
RESULTS & DISCUSSION
Crystal Structure
O

Fe Tetrahedral

Fe Octahedral

  𝐾.𝜆
𝐷=
Lattice 𝛽 . 𝑐𝑜𝑠 𝜃
Sample parameter Volume (Å3)
(Å) the crystal grain size of Fe3O4 /
Fe3O4/PEG 9.359 584.04 PEG and Fe3O4 / PEG /
Curcumin nano particles were
Fe3O4/PEG/Curcumin 8.346 581.3
10.145 nm and 9.746 nm.
Morphology
Functional group
Magnetic Behavior
DRUG RELEASE
120
Fe3O4/PEG/Cur
Fe3O4/PEG

(Cumulative release (%)) 100

80

60

40

20

0 50 100 150 200 250 300 350 400

times (minutes)
 CONCLUSION
• Fe3O4/PEG and Fe3O4/PEG combined with curcumin as a nanoparticle
has been successfully synthesized.
• The results of the analysis of X-ray diffraction data showed that both
sample formed Fe3O4.
• Functional groups Fe3O4 and PEG represented with Fe-O, C-O-C stretch
dan C-H stretch, while the addition of curcumin has a new peak namely
C=O and C-C .
• The average diameter size of Fe3O4/PEG particles is 23.4 nm and
Fe3O4/PEG/Curcumin particles are 22.6 nm.
• The value saturation magnetization (Ms) of sample Fe 3O4/PEG decreased
after adding curcumin. Fe3O4/PEG and Fe3O4/PEG/Curcumin
nanoparticles have potential as drug delivery agents
Acknowledgement

Fundamental Research Grant from

Kemenristekdikti RI
Preparation and Characterization of Magnetite/PEG Nanoparticles
Combined with Curcumin for Drug Delivery System

THANK YOU 

International Conference on Life Sciences and Technology

ICOLIST 2019 September, 12 – 13 2019