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CH 16
CH 16
CH 16
Microbiology Chapter 16
Microbiology Chapter 16
Type 1 Hypersensitivity – Anaphylaxis (Pg. ___)
1. Occurs quickly 2 – 30 minutes
2. Involves IgE antibodies
3. Can be localized hypersensitivity or generalized
a. Localized common allergic reaction like hay
fever, food allergies
b. Generalized – affect breathing, drop in blood
pressure
4. Sensitizing results in production of IgE antibodies,
2nd exposure causes
IgE ab bind with surface of mast cells (in
tissues) and basophils (blood)
Microbiology Chapter 16
a. Symptoms are related to these cells
degranulating and dumping of chemical
mediators like histamine
b. Histamine, most well known, causes
vasodilation, edema, swelling, redness (common
hay fever)
c. Other mediators can cause the symptoms of
asthma
d. Systemic anaphylaxis – injected allergens in
particular, drop in blood pressure (shock) can
be fatal in minutes – insect stings, penicillin
(hapten)
Fig. 16.3
Fig. 16.4
Microbiology Chapter 16
Microbiology Chapter 16