Thiophenes

REACTIONS AND SYNTHESIS

Reactions with Electrophilic Reagents
Substitution at Carbon- Protonation-Trimer formation
Nitration
Sulfonation
Halogenation
Acylation
Condensation with Aldehydes and
Ketones
Reaction with Isatin
Condensation with Imines and Iminium
Ions- Mannich reaction
Petasis reaction-Use of Boronic acids
Reactions with Nucleophilic Reagents
Reactions with Radicals
Reactions with Reducing Agents
Thiophene - C – X Compounds:
Thenyl Derivatives
Thiophene Aldehydes and Ketones,
and Carboxylic Acids and Esters
Oxy - Thiophenes
Synthesis of Thiophenes
-Ring Synthesis- From 1,4 - Dicarbonyl Compounds and a Source of Sulfide
From Thiodiacetates and 1,2 - Dicarbonyl Compounds
The Hinsberg Synthesis
From Thioglycolates and 1,3 - Dicarbonyl Compounds
From a - Thio - Carbonyl Compounds
From Thio - Diketones
Using Carbon Disulfide
From Thiazoles
From Thio - Nitroacetamides
From Sulfur, a - Methylene - Ketones and Malononitrile or Cyanoacetate
(The Gewald Synthesis)
THANKS