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  • Ketoconazole

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    shaharyar baig
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    Ketoconazole is an orally effective broad spectrum antifungal that is effective against dermatophytosis, deep mycosis, and candidiasis. It is readily absorbed in the acidic environment of the stomach and highly protein bound. While it is readily distributed, it does not cross the blood brain barrier. It is metabolized in the liver and excreted in bile with a half life of 8-10 hours. Common adverse effects include nausea, vomiting, anorexia, headache, and liver enzyme elevation. It interacts with other drugs and is used to treat dermatophytosis, monilial vaginitis, and some systemic mycoses, though it is less effective than amphot

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    Ketoconazole is an orally effective broad spectrum antifungal that is effective against dermatophytosis, deep mycosis, and candidiasis. It is readily absorbed in the acidic environment of the stomach and highly protein bound. While it is readily distributed, it does not cross the blood brain barrier. It is metabolized in the liver and excreted in bile with a half life of 8-10 hours. Common adverse effects include nausea, vomiting, anorexia, headache, and liver enzyme elevation. It interacts with other drugs and is used to treat dermatophytosis, monilial vaginitis, and some systemic mycoses, though it is less effective than amphot

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    18 views5 pages

    Ketoconazole

    Uploaded by

    shaharyar baig
    Ketoconazole is an orally effective broad spectrum antifungal that is effective against dermatophytosis, deep mycosis, and candidiasis. It is readily absorbed in the acidic environment of the stomach and highly protein bound. While it is readily distributed, it does not cross the blood brain barrier. It is metabolized in the liver and excreted in bile with a half life of 8-10 hours. Common adverse effects include nausea, vomiting, anorexia, headache, and liver enzyme elevation. It interacts with other drugs and is used to treat dermatophytosis, monilial vaginitis, and some systemic mycoses, though it is less effective than amphot

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 5

    Ketoconazol

    e
    – First orally effective broad spectrum antifungal
    – Effective against
    • Dermatophytosis, Deep mycosis , Candidiasis
    Pharmacokinetics
    • Effective orally
    • acidic environment
    favours
    absorption
    • High protein
    binding
    • Readily distributed, not to
    BBB
    • Metabolized in liver,
    excreted in bile
    • t1/2 = 8- 10 hrs
    Adverse events
    • Nausea , vomiting , anorexia
    • Headache , paresthesia, alopecia
    • ↓ steroid, testosterone & estrogen
    synthesis
    – Gynaecomastia, oligospermia , loss of
    libido &
    impotence in males
    – Menstrual irregularities & amenorrhoea
    in females
    • Elevation of liver enzymes
    • Hypersensitivity reaction - skin rashes,
    Drug Interactions
    Uses
    • Dermatophytosis: conc in stratum corneum
    • Monilial vaginitis : 5-7 days
    • Systemic mycosis: blastomycosis,
    histoplasmosis, coccidiodomycosis
    – Less efficacy than AMB & slower
    response
    – ↓Efficacy in immunocompromized
    and meningitis
    – Lower toxicity than AMB higher than
    triazoles
    • High dose used in cushings

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