ANTIBIOTIC :-

PENICILL
UDAY DUNGARANI.
Id:-18580127
Mail :- 7527@eu.edu.ge
CEPHALOSPORINS
 Cephalosporins are derivatives of 7-aminocephalosporanic acid and contain the beta-lactam
ring structure.
 Most important thing is that cephalosporins have cross reaction with penicill so avoi in that
patients who have anaphylactic shock by penicill.

 PHARMACOKINETICS

1. Oral,perentral both form

2. cephalosporins with side chain under go HEPATIC METABOLISM
3.
 1 ST GENERATION

 Most of drugs are more affective to gram positive

 Cefazolin. G(+) = streptococcus
.LIN Stpylococcus
1. Cephalexin .XIN Echoli
K - pneumoniae

Uses :- UTI, Surgical prophylaxis (chest, abdomen,pelvis),step throat

Toxicity:- Anaphylactic shock, Hypersensitivity reaction (hypotension, bronchoconstriction,skin rashes

and burning
2 ND
GENERATION
 Not G(+) affective as first generation, but good on G(-) effects

1. Cefotetan .Tan Bacteria

.Tin Bacteroids fragilis
2. Cefoxitin

 Ear, respiratory,sepsis infection like H. Influenzae or M. Caturrhalis

.dole
.ime
.clor
Cefamandole
Cefuroxime
1. Cefuclor