Cefuroxime

A Drug Study Presented to

Lendell Kelly B. Ytac, RN
Faculty, INAHS BSN-Program
Davao Oriental State University

_____________________________________________

In Partial Fulfillment
of the requirements for
NCM 118
Care of Clients with Life Threatening Conditions, Acutely Ill / Multi-Organ Problems,
High Acuity and Emergency Situations

By

Clint S. Ancog
Student Nurse, BSN-4

October 12, 2022

 Name of Drug Dosage/ Mechanism of Indication Contraindication Side Effects/ Nursing
Frequency/ Action Adverse Effects Responsibilities
Time/ Route
Generic Name: Usual Dosage Binds to bacterial Cefuroxime is History of SIDE EFFECTS: BASELINE
Cefuroxime cell membranes, a hypersensitivity/ Frequent: ASSESSMENT
IV, IM: inhibits cell wall cephalosporin anaphylactic Discomfort with IM Obtain CBC,
Brand Name: ADULTS, synthesis. indicated for reaction to administration, oral renal function
 Cefrin ELDERLY, Therapeutic the treatment cefuroxime, candidiasis (thrush), tests. Question for
CHILDREN 12 Effect: of a variety of cephalosporins. mild diarrhea, mild history of
Drug YRS AND Bactericidal. infections abdominal allergies,
Classification: OLDER: 750 including Cautions: Severe cramping, vaginal particularly
Cefuroxime is mg–1.5 g q8h up Pharmacokinetics: acute bacterial renal impairment, candidiasis. cephalosporins,
used to treat to 1.5 g q6h for Rapidly absorbed otitis media, history of penicillins.
bacterial infections severe from GI tract. several upper penicillin allergy. Occasional: Nausea,
in many different infections. Protein binding: respiratory Pts with hx of serum sickness–like INTERVENTIO
parts of the body. 33%–50%. Widely tract colitis, GI reaction (fever, joint N/
It belongs to the CHILDREN: 3 distributed, infections, malabsorption, pain; usually occurs EVALUATION
class of medicines MOS TO including to CSF. skin seizures. after second course Assess oral cavity
known as YOUNGER Primarily excreted infections, of therapy and for white patches
cephalosporin THAN 12 YRS: unchanged in urine. urinary tract resolves after drug is on mucous
antibiotics. Moderately infections, discontinued). membranes,
Mild to removed by gonorrhea, tongue (thrush).
Chemical make-up moderate hemodialysis. early Lyme Rare: Allergic Monitor daily
and effect: infection: 75 disease, and reaction (rash, pattern of bowel
100 mg/kg/day Pharmacodynamic impetigo. pruritus, urticaria), activity, stool
Cefuroxime is a 3- divided q8h. s: thrombophlebitis consistency. Mild
(carbamoyloxymet Maximum: Cefuroxime is a (pain, redness, GI effects may be
hyl) cephalosporin 1,500 mg/dose second-generation swelling at injection tolerable
compound having cephalosporin with site). (increasing
a 7-(2Z)-2-(furan- Severe a broad severity may
2-yl)-2- infection: 100- antimicrobial ADVERSE indicate onset of
(methoxyimino)ac 200 mg/kg/day activity against EFFECTS: antibiotic
etamido side divided into 3–4 both Gram-positive Antibiotic- associated
chain. It has a role doses. associated colitis,
as a drug allergen. Maximum: and Gram-negative other superinfections colitis). Monitor
It is a 3- 1,500 mg/dose. organisms. It has (abdominal cramps, I&O, renal
(carbamoyloxymet excellent in vitro severe watery function tests for
hyl)cephalosporin, NEONATES: activity against diarrhea, fever) may nephrotoxicity.
a member of 50 mg/kg/dose staphylococcal result from altered Be alert for
furans and an q8–12h. strains, bacterial balance in superinfection:
oxime O-ether. streptococcal GI tract. fever, vomiting,
Cefuroxime is a PO: ADULTS, strains (other than Nephrotoxicity may diarrhea,
Cephalosporin ELDERLY, enterococci), N. occur, esp. in pts anal/genital
Antibacterial. CHILDREN 12 gonorrhoeae, H. with preexisting pruritus, oral
YRS AND influenzae and N. renal disease. Pts mucosal changes
OLDER: 250– with history of (ulceration, pain,
500 mg twice a penicillin allergy are erythema).
day at increased risk for
developing a severe PATIENT/
CHILDREN 3 hypersensitivity FAMILY
MOS TO reaction (severe TEACHING
YOUNGER pruritus, • Discomfort may
THAN 12 YRS: angioedema, occur with IM
20–30 bronchospasm injection.
mg/kg/day in 2 anaphylaxis). • Doses should be
divided doses. evenly spaced.
Maximum: 1 • Continue
g/day (500 antibiotic therapy
mg/dose). for full length of
treatment.
• May cause GI
upset (may take
with food, milk).
References:

Carone S., & Bornsrtein M. (n.d). Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral
Administration. DrugBank Online. Retrieved from: https://go.drugbank.com/drugs/DB01327#references-header

Kizior R. J., & Hodgson K. J. (2021). Saunders Nursing Drug Handbook 2021. Elsevier. 3251 Riverport Lane. St. Louis, Missouri
63043.