DRUG NAME MECHANISM OF ACTION
GENERIC: Tranexamic acid
Tranexamic acid competitively and reversibly
Brand Name: inhibits the activation of
Cyklokapron, Lysteda plasminogen via binding at
THERAPEUTIC CLASS: several distinct sites,
Hemostatic Agent including four or five low-
Pharmacologic: affinity sites and one high-
Antifibrinolytic Agents affinity site, the latter of
which is involved in its
binding to fibrin. The binding
Dosage ordered: of plasminogen to fibrin
500 mg induces fibrinolysis - by
occupying the necessary
ROUTE: binding sites tranexamic acid
IV prevents this dissolution of
fibrin, thereby stabilizing the
clot and preventing
hemorrhage
Therapeutic Effects:
Bactericidal action
against susceptible bacteria
INDICATION / CONTRAINDICATION
INDICATIONs:
 Treating
CONTRAINDICATION:
 Hypersensitivity to
cephalosporins; Serious
hypersensitivity to penicillins.
DRUG TO DRUG INTERACTION:
Probenecid excretion and blood
levels of renally excreted
cephalosporins. Concurrent
use of loop diuretics or
aminoglycosides may 
risk of renal toxicity.
ADVERSE EFFECT NURSING RESPONSIBILITIES
CNS: Dizziness Dx
GI: diarrhea, nausea,
vomiting
CV: Hypotension,
Thromboembolism,
Thrombosis
EENT: Visual Abnormalities
 Assessed for drug hypersensitivity
 Observed the 10 Rs of drug
administration
 Assess for infection (vital signs;
appearance of wound, sputum,
urine, and stool; WBC) at
beginning and during therapy.
 Monitored site frequently for
thrombophlebitis
Tx:
 Reconstitution drug varies by
size or package; see
manufacturer’s directions for
details
 Injected deep into a well-
developed muscle mass;
massage well.
 If aminoglycosides are
administered concurrently,
administer in separate sites, if
possible, at least 1 hr apart.
If second site is unavailable,
flush line between
medications.
Edx:
 Advised patient to report
signs of superinfection (furry
overgrowth on the tongue,
 vaginal itching or discharge,
loose or foul-smelling stools)
and allergy.
 Instruct patient to notify
health care professional if
rash, or fever and diarrhea
develop, especially if diarrhea
contains blood, mucus, or
pus. Advise patient not to
treat diarrhea without
consulting health care
professional.