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  • Organic Fine Chemicals Fermentation Process

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    The document summarizes the fermentation process used in the manufacture of organic fine chemicals. It describes how fermentation uses living organisms like yeast and bacteria to induce chemical changes. It outlines the key stages of seeding to develop microorganisms and the fermentation stage in large stirred vessels. The document discusses waste streams produced, including biomass, filtered broth, and exhaust gases. It provides examples of treatments for these wastes, such as incineration, biological waste treatment plants, scrubbing, and carbon adsorption.

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    Presentation on EU BREF Regulations

    Original Title

    BREF PRESENTATION-Moneem

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    The document summarizes the fermentation process used in the manufacture of organic fine chemicals. It describes how fermentation uses living organisms like yeast and bacteria to induce chemical changes. It outlines the key stages of seeding to develop microorganisms and the fermentation stage in large stirred vessels. The document discusses waste streams produced, including biomass, filtered broth, and exhaust gases. It provides examples of treatments for these wastes, such as incineration, biological waste treatment plants, scrubbing, and carbon adsorption.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    13 views9 pages

    Organic Fine Chemicals Fermentation Process

    Uploaded by

    pepina
    The document summarizes the fermentation process used in the manufacture of organic fine chemicals. It describes how fermentation uses living organisms like yeast and bacteria to induce chemical changes. It outlines the key stages of seeding to develop microorganisms and the fermentation stage in large stirred vessels. The document discusses waste streams produced, including biomass, filtered broth, and exhaust gases. It provides examples of treatments for these wastes, such as incineration, biological waste treatment plants, scrubbing, and carbon adsorption.

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    © All Rights Reserved
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    of 9

    Manufacture of Organic

    BREF PRESENTATION Fine Chemicals -


    By Moneem Ahmed Fermentation
    FERMENTATION PROCESS

    • Utilise a chemical change induced by a living organism or enzyme


    • Yeast
    • Bacteria
    • Mould
    • Applications include
    • Production of modification of the U-lactam antibiotics
    • Production of penicillins and cephalosporins
    • Brewing of alcoholics such as wine and beer
    STAGES

    Seed Stage: Fermentation Stage


    • Develop a population of microorganisms
    • Carried out in a large stirred fermenter (up to 200 m3)
    using the previous batch inoculate the next
    • Process is highly controlled by design with sterilizing
    • Microorganism can be pathogenic medium and steam being used to ensure optimal
    • Growth medium used are usually non- growth and quantity of microorganisms
    volatile and don’t require special precautions • Product Separated by:
    • Filtration (conventional and ultrafiltration)
    • Corn steep liquor • Solvent Extraction
    • Rapeseed oil • Ion Exchangers coupled with pH adjustments
    • Spray drying of unfiltered broth
    • Starch hydrolysate
    BAT CONSIDERATIONS

    1. Prevention of environmental impact


    2. Minimisation of environmental impacts

    3. Management and treatment of waste streams


    4. Environmental Management Tools
    WASTE STREAMS AND TREATMENTS I

    Biomass, possibly containing • If hazardous, treatment with heat,


    active pharmaceutical chemicals or vacuum evaporators at
    ingredients and possibly 85 to 90 °C to lower activity
    filtration auxiliaries • Incinerated at 1100 °C at least 2
    secs
    Filtered broth, possibly
    containing active
    pharmaceutical ingredients and Usually treated in a biological WWTP
    precipitation auxiliaries
    WASTE STREAMS AND TREATMENTS II

    • In-vessel detector is used to


    Exhaust gas from seed and automatically close the exhaust valve or
    to control the addition of an
    fermentation stages, antifoaming agent
    containing broth aerosol
    • Backed-up by a downstream cyclone or
    thermal oxidator

    • Stack gas scrubbing, with hypochlorite


    VOC from solvent use • Carbon adsorption (low loads)
    • Biofilters (needs prior cooling)
    THANK YOU FOR YOUR ATTENTION

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