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• Study Design:
• Prospective and with blinded statistical analysis
• Inclusion Criteria
• July 2002 to July 2004
• From July 2002 to June 2003 (Group I) the patients had surgery without vitamin C, and from
July 2003 to June 2004 (Group II) received preventive vitamin C treatment: 1 g on the first
postoperative day, and then each morning for 45 days.
• Compliance was checked at 3 weeks and 3 months. In case of non-compliance, patients were
excluded from analysis.
Materials and Methods
• Exclusion Criteria
• Diabetic patients were excluded. These patients’ pain status is hard to estimate.
• Methodology
• Age, sex, history of CRPS I, psychological context of anxio-depression, type of presenting
pathology, type of anesthesia, surgical procedure, tourniquet time, post-operative cast, and
non-weight bearing time.
• Xray 10th, 21st and 45th day post-operatively, and then every 3 months
• The diagnosis of CRPS I was made from clinical data as proposed by the IASP criteria: in the
presence of the set A criterion or at least two set B criteria
Materials and Methods
Materials and Methods
• Patients included
• 420 feet (392 patients) included.
• Group I without vitamin C
comprised 185 feet: 177 patients
(44 males, 133 females).
• Group II with vitamin C comprised
235 feet: 215 patients (49 males,
166 females).
Results
• Effect of vitamin C
• CRPS I occurred in 9.6% of Group I patients (n = 18), as against 1.7% (n = 4) in Group II (p <
0.0001).
• One patient stopped vitamin C after 1 day’s treatment, and went on to develop postoperative
CRPS I; he was excluded from analysis.
Results