A -

GM-
Brings FruTE-
Cuts MIXs with Big Hands-
And Starts Taking-
A - Acetazolamide
Carbonic Anhydrase Inhibitors (Site I)

GM- Glycerine, Mannitol Osmotic Diuretics (Site I, II and…)

Brings FruTE- Bumetanide, Furosemide,

Torasemide, Ethacrynic acid Loop Diuretics (Site III)

Cuts MIXs with Big Hands-

Clopamide, Chlorthalidone, Metolazone, Indapamide, Xipamide,
Benzthiazide, Hydrochlorthiazide, Thiazide Diuretics (Site IV)

And Starts Taking- Amiloride,

Spironolactone, Triamterene Potassium Sparing Diuretics (Site V)
Diuretic Site of Action Adverse Effects Special points
Carbonic PTC Metabolic Acidosis Weak, Used in Glaucoma, Petit mal epilepsy,
anhydrase (inhibition of CAE) Acute mountain sickness, to alkaline the urine
inhibitors

Osmotic PTC, LOH, DCT Shifting of fluid from Potent

Diuretics (Osmotic retention of intracellular to Used in Glaucoma, Poisoning, Increased ICT,
water, Dilates Afferent extracellular, impending ARF
arterioles, Increased Hyponatremia,
hydrostatic pressure in Pulmonary edema
glomerulus

Loop Thick Ascending Limb of Hyponatremia Most potent, Most Potent is Bumetanide,
Diuretics Henle Hypomagnesaemia Effective even in low GFR, All except
(NaK2Cl inhibition) Hypocalcaemia Ethacrynic acid are sulphonamide related,
Weak CAI action Hyperuricemia Venodilatation, Decrease Left Ventricle
Hyperglycemia Pressure, Used in Acute LVF, Pulmonary
Hyperlipidemia Edema, Nephrotic syndrome, ARF, NSAIDS
Hyperuricemia blunt effect, Cerebral edema, short term tt of
Ototoxic (ECA) Hypertension, to reduce volume overload during
transfusion,

Thiazide DCT Hypokalemic Moderate, Chlorthalidone is Longest acting,

Diuretics (NaCl) metabolic alkalosis Paradoxical effect in Diabetes Insipidus
(Gitelman’s First line in Hypertension,
Syndrome)
Hypercalcemia

Potassium CD HyperKalemia Weak, As supplement to other to counter the

Sparing Antiandrogenic hypokalemia, Canrenone is active metabolite, used in
Conn’s syndrome (Primary Hyperaldosteronism)
Diuretics effect
cirrhotic edema, polycystic ovary