Professional Documents
Culture Documents
• Neoantigen formation
• ^ce mark EU
Production of red cells from ES cells or from
somatic stem cells?
• Human erythropoiesis - a complex multistep process
involving the differentiation of early erythroid
progenitors to mature erythrocytes
• Human Embryonic Stem Cells (HES)
– 2 recent papers show that viable mature functional
enucleated RBCs can be produced in vitro from ES cells in
numbers - suitable for up-scaling
– Large recent investment by research bodies to develop
these techniques
• HLA-haplotype banking and iPS cells?
– Induced pluripotent stem cells (iPS) from human somatic
stem cells such as skin fibroblasts recently reported
% Receiving
% Not receiving
Increase
0%
Decrease
100%
< 0.3 0.3–0.5 > 0.5
Iron intake (mg/kg/day)
100
Increase (%)
Decrease (%)
0.6
± SD (mg Fe/kg/day)
0.5
Average transfusion iron intake
0.4 thalassaemia
0.3
0.1