Health talk on

Dengue
VIGNESH S
(N0119005)
Specific objectives ;
 Definition
 Cause of dengue fever
 Pathogenesis of dengue fever
 Symptoms of dengue fever
 Diagnosis and findings of
dengue fever
 Treatment of dengue fever
 Complications of dengue fever
Dengue fever
• Dengue fever, commonly known as break
bone fever is a flu-like illness caused by the
Dengue virus. It is caused when an Aedes
mosquito carrying the virus bites a healthy
person.
• Flave virus
• Single standard & non segmented
RNA virus
• 4 serotypes
Causes :
 Dengue is caused due to four viruses, namely - DENV-1,
DENV-2, DENV-3, and DENV-4. The virus enters a mosquito
when it bites an already infected person. And the illness is
spread when it bites a healthy person, and the virus spreads
through the person’s bloodstream.

 Once a person recovers, he is immune to the specific virus and

not the other three types. The probability of developing severe
Dengue fever, also known as Dengue Haemorrhagic Fever,
increases if you're infected a second, third or fourth time.
Pathogenesis of dengue:
 Secondary infection

Pre existingnon neutraslysing antibodies oppes the

virus.

Enchance viral uptake and replicate

marcophages.

Lead to higher loads.

Symptoms
 Fever
:  Head ache
 Muscle and joint pain
 Nausea, vomiting
 Eye pain
 Rashes
 Enlarged lymph nodes
 Fever lasts 2-7 days
 Mualiya and break bone fever
 DHF (mouth and nose bleeding).
Mild Dengue Fever – Symptoms are seen
after a week from the bite and include severe
or fatal complications.
Dengue Haemorrhagic Fever – Symptoms
are mild but can gradually worsen within a
few days.
Dengue Shock Syndrome – This is a severe
form of dengue and can even cause death.
Diagnosis:
Dengue be suspected in a patient with compatible of signs
and symptoms and who lives recently travelled to a
diseases to a endemic area typically present with :

 Fever
 Headache
 Body pain
 Sometimes rash
 Nucleic acid amplication test
(NAATs) ; preferred method of
diagnosis
 rRt-PCR- to detect viral genome
method (<7 days of symptoms onset)
 Detection of NS1 antigens - by immunoassay(<7
days)
 Serology test - presence of antibodies agents
DENV IgM against DENV
 Patient present with first week of IgM +
DENV/NAAT.
 Patient present >1 week IgM.

 False positive : cross positive with other

flavivirus (Zika,JE.) IgG not useful.
Laboratory findings:

1. Thrombocytopenia
2. Luekopinea
3. Mild moderate elevation of
ALT/AST
Severe damage:
• Increased HTC
• Hypoproteinemia
Treatment:
① No specific antiviraldrug is available.
② Well hydrated.
③ Avoid aspirin & NSAIDs.
④ To control fever : Aceaminophen
(panadol)
⑤ Tepid sponging .
⑥ Avoid mosquito bites- reduce
Severe dengue:
• Close observation & frequently
monitoring.
• Dehydration- IV fluids.
• Coagulopathy -fresh, frozen
plasma.
• Prophylactic platelet infection .
Complications:
• Hpocalcemia
• Hypoglycemia
• Hyperglycemia
• Liver damage
• Hypotension
• Fluids and electrolytic
loss.
Which virus cause dengue?

a. Measles
b. Rubella
c. Falvi
d. Roseola
The dengue virus is which
standard DNA ?
a. single standard
b. Double standard
 What is mean by
thrombocytopenia?
a. Body produces low
platelets.
b. Body produces too
many platelets.