MICRONEEDLE

TECHNOLOGY

PRSENTED BY:-
PRIYAN
KA
MANDAL
ROLL NO-
B14057 SEM-6;
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MICRONEEDLE TECHNOLOGY uses
devices consisting of hundreds or even
thousands of tiny microscale needles that
are arranged in a orderly array of rows and
columns.

HISTORY :-
 First Microneedles were reported
by
Albert Pisano(1993) & Ken Wise
(1994).
 In 1998, a team led by Mark R.
Prausnitz and Mark G. Allen produced
microneedle that struck out of the
plane.

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 Advance drug delivery system

Simple, inexpensive and self -administrated

Greater patient satisfaction

Dermatological therapy

Easily disposable

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:-

Painless drug delivery system.

Rapid onset of action.

Possible self -administrated

Avoids first-pass effect.

Easily disposable and

potentially biodegradable

Cost effectively low

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 :-
SOLID

COATE
D

MICRONEEDLE

DISSOLVING

HOLLOW

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 Solid microneedles are of three
types :-
 Silicon
Metal
Polymer

Used as a pretreatment for

pore formation in skin in order
to make holes through which
drugs can transport.
Increase the permeability by
pocking the holes in skin, rub
drug over area or coat needle
with drug.

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 Coated microneedle pierce
the skin surface and also carry
drugs across the membrance.

COATING SOLUTION Coating solution contains :-

 Drugs
Exipients (like agent,
surfactant,stablizers
thickening etc.)
Eudragit E Propylene One example of coating solution
Minoxidil
100 glycol of Minoxidil, used in the treatment
of Alopecia

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It involves encapsulating
the drug within the Polymers used:
biodegradable,polymeric
microneedles, followed PLA, PGA, PLGA,
by the insertion into the PVP,
skin for drug release Polycarbonate

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MECHANISM

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MECHANISM

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POKE AND PATCH APPORACH COAT AND POKE APPORACH

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POKE AND RELEASE APPORACH POKE AND FLOW APPORACH

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 Laser cutting

MEMS technology

Electropolishing
Photolithography

Micro-dip-coating

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 Margin of safty
ratio is <1
Effect of the Length of microneedle on pain
Increase in needle length increases pain

Transepidermal water loss

MEASURE TEWL

Biological safety test

Negative result reveals the biological
safety

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 In vitro In vivo
• It is carried out to • Preclinical evaluation
determine optimization of microneedles was
of microneedles, performed on animals
penetration force, like mice and guinea
strength of pig in order to
microneedles, delivery determine the delivery
efficacy etc. efficacy, penetration
force, bending force
and to evaluate the skin
toxicity testes using
vaccine delivery

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 MICRONEEEDLE

Cellular delivery Systemic delivery

Can be used to Local delivery Helps over coming
deliver membrane Targeted delivery limitations of
impermeable helps reduce side conventional
molecules into the effects, minimize the
injections
cells dose and helps deliver
drug to locations
difficult to treat

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 • Microneedles have an edge over the other
methods due to lack of pain .Eg: influenza
Immunobiologicals vaccine, hepatitis B vaccine ,flavivirus vaccine
etc

• Insulin, heparin, and growth hormones,

parathyroid hormone, human growth
Biopharmaceuticals hormone, desmopressin can be delivered by
microneedles

• Diclofenac, lidocaine, naltrexone, doxetaxel etc

can be administered via microneedles
Drugs

• Phlebotomy is the withdrawal of

Phlebotomy blood for diagnostic purpose
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 Tips may broken off

Local inflammation may occur

Sometimes difficult to apply

Skin irritation may occur due to sensitive skin

Large range of drugs are still not used to deliver

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