PRESENTED BY- AMEENA MEHABOOB

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 INTRODUCTION

 Microneedles can be defined as the solid or

hollow cannula with an insertion length of
approximately 20 to 1500 microns and the
external diameter of not more than approximately
30 microns.

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 TYPES

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MECHANISM OF ACTION
•Solid microneedles creates microscopic holes followed by application
of drugs from patch
• Hollow microneedles puncture skin followed by infusion through
needle bores.
FABRICATION
MATERIALS USED

METHOD

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 EVALUATIO
N
MARGIN MEASUREMENT MEASUREMENT BIOLOGIC FUNCTIONAL
PENETRATIO
OF OF FRACTURE OF INSERTION AL SAFETY
N TEST
CAPACITY
SAFETY FORCE FORCE TEST TEST

METHODS OF DRUG DELIVERY

Poke with Biodegradable Hollow

Coat and poke Dip and scrape
patch microneedles microneedles

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 ADVANTAGE DISADVANTAGES
S
Pain free administration Skin irritation due to allergy

Safer handling Local inflammation

Easy to use Can be difficult to apply

Discreetness Tips may be broken off due to

small size

TYPES OF MICRONEEDLE
DEVICES

Collagen Electrically Microelectro- Integrated Membrane-

induced conductive automatic microneedle sealed
therapy with micro needle pump systems microneedles
microneedle roller
6 Derma
roller
 APPLICATIONS
CELLULAR DELIVERY
INSULIN DELIVERY

DNA VACCINE DELIVERY

DESMOPRESSIN DELIVERY
PROTEIN VACCINE DELIVERY
TRANSDERMAL DRUG DELIVERY
LOCAL TISSUE DELIVERY
SYSTEMIC DELIVERY
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MICRONEEDLE SKIN THERAPY
 FUTURE PROSPECTIVE
•Encapsulation of microneedle for oral insulin
delivery.
• Immunization programs
• Mass vaccination
• Administration of antidotes in bioterrorism
incidents.
• Removal fluids from the body

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 CONCLUSION
 Microneedles can be fabricated by a number of
different methods to yield a variety of needle
sizes, shapes and materials. Proper needle
design can assure insertion into the skin that
prevents needle fracture or patient pain.
 These painless systems are slowly gaining
importance and would qualify to be one of the
important devices for controlled drug release in
future. Thus, it was concluded that these systems
represented it to be an efficient and superior
carriers as compared to other needle based
9 formulation for the transdermal delivery.
 REFERENCES
1.M. R. Prausnitz, S. Mitragotri, R. Langer. Current status and future
potential of transdermal drug delivery. Nature Reviews Drug Discovery.
2004; 3(2):115–124.
2.Barry B.W. Novel mechanisms and devices to enable successful
transdermal drug delivery. European Journal of Pharmaceutical
Sciences.
2001; 14(1): 101-114.
3.Vandervoort J, Ludig A. Microneedles for transdermal drug delivery: a
minireview. Frontiers in Bioscience. 2008; 1(13): 1711-1715.
4.Tabassum N, Sofi A, Khuroo T. Microneedle technology: a new drug
delivery system. International Journal of Research in Pharmaceutical
and Biomedical Sciences. 2011; 2(1): 59-62.
5.Kumar V, Kulkarni P, Raut R. Microneedle: Promising technique for
transdermal drug delivery. International Journal of Pharmaceutics and
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Biosciences 2011; 2(1): 684-670.
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