SISTEM PENGHANTARAN

OBAT
Dr. rer. medic. apt. Robert Tungadi, M.Si
Novel Drug Delivery System
A combination of advance technique and new dosage
forms which are far better than conventional dosage
forms
Advantages :
Optimum dose at the right time and right location
Efficient use of expensive drugs
excipients and reduction in production cost
Continued
better therapy
Beneficial to patients
 Basic modes of novel drug delivery
systems are:
• Targeted Drug Delivery System
• Controlled Drug Delivery System
NOVEL CARRIER FOR CONTROLLED &
TARGETED DRUG DELIVERY
These newly developed drug have high potency (low
therapeutic window) and required their localization of
the particular site of their action
Most drugs are administrated by conventional
immediate- release dosage forms.
They distribute freely throughout the body &
accumulate the non – specific organs in an undesirable
manner and thus produce adverse side effects
To reduce these slides and increased their therapeutic
benefits, they should be delivered to their respective
site of action, and hence suitable carrier systems
becomes mandatory requirement
Various novel carriers have been developed for the
purpose
Among these colloidal carriers such as liposomes,
nano- particles & supra molecular system, i.e. micelles
have gained more attention in the field of controlled
and targeted drug delivery.
Colloidal carrier
LIPOSOMES
Liposomes were discovered in the early 1960s by
Bingham and co-workers and subsequently became
the most extensive- explored drug -delivery system
liposomes are phospholipid -based colloidal vesicular
structures in which hydrophilic core is entirely
enclosed by membranous lipid bilayer’s
NIOSOMES
Non – ionic surfactants vesicles (niosomes) or NSVS)
are now widely studied as an alter -native to liposomes
Non – ionic surfactants of wide variety of structural
types have been found to be useful alternatives to
phospholipids
Distinctions exist between niosomes and liposomes of
which the former is having chemical differences in the
monomers units, niosomes posses physical properties,
which are similar to liposomes, which are formed from
phospholipids
However, they may also prepared with various ionic
amphiphiles such as dicetylphosphate, stearylamine,
etc
These can be broadly divided into two classes based
on nature of their hydrophilic head groups, i.e. Alkyl
ethers in which the hydrophilic head group consists of
repeat glycerol subunits, related isomers or larger
sugar molecules, and those in which the hydrophilic
head group consists of repeat ethylene oxide subunits.
Niosomes have been proven to be useful in the
delivery Of anti-infective agents, anti- cancer agents,
anti-inflammatory agents, and fairly recently, as a
vaccine adjuvants.