Antibiotic classification on the

basis of mode of action

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Antibiotic Classification

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 Quinolones
Inhibitors of DNA replication

Broad‑ spectrum bactericidal activity

Effective in skin and respiratory infections

Nalidixic acid, cinoxacin and oxolinic acid

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Mechanism of Action

Blocks

DNA Topoisomer-
Gyrase -ase IV

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 Mechanism of Action
Inhibition of DNA gyrase prevents the
relaxation of positively supercoiled DNA that
is required for normal transcription and
replication

Inhibition of topoisomerase IV interferes with

the separation of replicated chromosomal
DNA into respective daughter cells during
cell division.
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Mechanism of Action

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 Sulfonamides
Inhibitors of folic acid metabolism

Necessary for amino acid synthesis

Antimicrobial activity against both Gram

+ve and Gram –ve bacteria

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Mechanism of Action

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