Dengue

Virus
Iqbal Ainnun Azis
Tutor 23
01
Overview
EPIDEMIOLOGY

Sekitar 50 hingga 100 juta kasus

terjadi setiap tahunnya dengan
sekitar 500 ribu pasien
membutuhkan perawatan di
rumah sakit dan kebanyakan
pasien adalah anak-anak.
TAXONOMY
Family
● Flaviviridae

Genus
● Flavivirus
STRUCTURE

Spherical, enveloped virus, 40-

60 nm in diameter, containing
single-stranded, positive-sense
RNA.
STRUCTURE

● Has 10 proteins:

- 3 Structural  form the coat

of the virus and deliver the
RNA to the cells target

- 7 Non structural  controls

the production of new viruses
inside the cell
 STRUCTURAL PROTEINS

C M E
Core protein Membrane-associated Envelope protein
protein
 NON-STRUCTURAL PROTEINS
NS
1 NS2A NS2B

- The amount of secreted

NS1 in patient serum
correlates with viremia
and DENV
pathogenesis NS3 NS4A NS4B
- NS1-based ELISA have
become an important
diagnostic tool for acute
samples in which IgM
is not detectable and
where PCR is not NS5
available
 SEROTYPE

DENV-1 DENV-2

DENV-3 DENV-4

Genetically similar but antigenically distinct

Also have a different geographical distributions
THAN
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