Preparation of Suspensions

The small-scale preparation of suspensions may be undertaken

readily by the practicing pharmacist with the minimum of
.equipment
The initial dispersion of the particles is best carried out by .
trituration in a mortar, the wetting agent being added in small
.increments to the powder
Once the particles have been wetted adequately, the slurry may be
transferred to the final container.
The next step depends on whether the deflocculated particles are
to be suspended in a structured vehicle, flocculated, or flocculated
and then suspended.
Pre-formulated vehicles are commercially available to
pharmacists to facilitate the extemporaneous preparation of
suspensions.
These products are essentially aqueous structured vehicles that
contain cellulosic suspending agents, surfactants, buffering
agents, and electrolytes.
Some products may contain sweetening agents. Pre-formulated
suspending vehicles are available at acidic or basic pH to
match physical and chemical stability requirements of
different drugs.