Professional Documents
Culture Documents
PHARMACEUTICAL
TECNOLOGY
(ESSENTIALS)
Part 2
1-Non- toxic
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Raw Materials For Gelatin Capsules
dipped
Metal moulds hot gelatin solution: gels to form
into
Dried, cut, removed from the moulds film
& two parts are joined together.
Filling
Hard gelatin capsules are most frequently filled
with powders
Suppositories
Advantages:
• Useful when it is desirable to seal the medication within the capsule. The
drug may hydrolyze or oxidize on long term storage.
drug poorly soluble in water or gastric juice and the bioavailability from
some solid dosage forms might be poor.
• The soft capsules are especially important to contain liquid drugs or drug
solutions → rapid release of the contents with enhanced bioavailability.
• Soft gelatin capsules are handsome and are easily swallowed by the
patient.
Disadvantages:
• Soft gelatin capsules are not easily prepared except on a large
scale and with specialized equipment.
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PREPARATION OF SOFT GELATIN
CAPSULES
Drip-feed Process
Rotary Die Process
Quality standards and compendial
requirements
Weight and weight variation
Content uniformity
Disintegration
Dissolution
in-process controls
verification after the production
Liquid
dosage forms
Liquid dosage forms are prepared:
(1) by dissolving the active drug
substance(s) in an aqueous or
nonaqueous (e.g. alcohol, ether,
glycerin) solvent, (2) by suspensing
the drug in appropriate medium, or
(3) by incorporating the drug
substance into an oil or water
phases.
Liquid dosage forms can be
administered:
• Topically - lotions or
suspension applied to the skin, eye drops,
nasal drops, ear drops
• Orally (p.o.) - oral
suspension and solution
• Parenterally -
subcutaneous injection (s.c.),
intramuscular injection (i.m.)
and intravenous administration (i.v.)
Sterile dosage forms for
injection
These forms contain solutions, powder
or lyophilized powder ready to be
dissolve, suspensions, and emulsions.
They are packaged in ampoules, vials,
plastic bags, one-point cut ampoules,
and prefilled disposable syringes.
Sterile dosage forms for
injection
Semisolid dosage forms
Ointments
Suppositories
Semisolid dosage forms
Ointments
Definition: semisolid preparations intended for
external application are termed ointments.
preparations Antioxidants
aqueous Sodium sulfite(Na2SO3)
sodium bisulfite(NaHSO3),
hypophosphorous acid(H3PO2)
ascobic acid( vitamin C)
oleaginous Alpha tocopherol(vitamin E)
Butylhydroxyanisole(BHA)
ascorbyl palmitate
Suppositories
Suppositories are semisolid dosage forms
intended for insertion into body orifices where
they melt, soften, or dissolve and exert localized or
systemic effects.
Suppositories
Suppositories are commonly employed rectally,
vaginally and occasionally urethrally.
High cost.