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  • HYPERPARATHYROIDISM

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    Shweta Das
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    This document discusses hyperparathyroidism, which occurs when the parathyroid glands secrete excessive amounts of parathyroid hormone (PTH) in response to low blood calcium levels. PTH acts to increase calcium levels by promoting its reabsorption in the kidneys, inhibiting phosphate reabsorption, and converting vitamin D to its active form. It also causes bone resorption by inducing osteoclast differentiation, leading to increased calcium release from bones. There are three types of hyperparathyroidism: primary due to parathyroid gland hyperplasia/adenoma/carcinoma, secondary due to hypocalcemia, and tertiary due to long-term secondary hyperparathyroidism. Treatment

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    This document discusses hyperparathyroidism, which occurs when the parathyroid glands secrete excessive amounts of parathyroid hormone (PTH) in response to low blood calcium levels. PTH acts to increase calcium levels by promoting its reabsorption in the kidneys, inhibiting phosphate reabsorption, and converting vitamin D to its active form. It also causes bone resorption by inducing osteoclast differentiation, leading to increased calcium release from bones. There are three types of hyperparathyroidism: primary due to parathyroid gland hyperplasia/adenoma/carcinoma, secondary due to hypocalcemia, and tertiary due to long-term secondary hyperparathyroidism. Treatment

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    30 views9 pages

    HYPERPARATHYROIDISM

    Uploaded by

    Shweta Das
    This document discusses hyperparathyroidism, which occurs when the parathyroid glands secrete excessive amounts of parathyroid hormone (PTH) in response to low blood calcium levels. PTH acts to increase calcium levels by promoting its reabsorption in the kidneys, inhibiting phosphate reabsorption, and converting vitamin D to its active form. It also causes bone resorption by inducing osteoclast differentiation, leading to increased calcium release from bones. There are three types of hyperparathyroidism: primary due to parathyroid gland hyperplasia/adenoma/carcinoma, secondary due to hypocalcemia, and tertiary due to long-term secondary hyperparathyroidism. Treatment

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 9

    HYPERPARATHYROIDISM

    PARATHYROID HORMONE
    PEPTIDE HORMONE RELEASED BY
    PARATHYRPOD GLANDS

    IN RESPONSE TO LOWERED PLASMA


    CALCIUM

    CALCIUM SENSING RECEPTORS


    ACTIONS OF PTH
    INCREASES CALCIUM REABSORPTION AT DISTAL
    TUBULE OF KIDNEY

    INHIBITS PHOSPHATE REABSORPTION AT


    PROXIMAL TUBULE OF KIDNEY

    CONVERTS INACTIVE FORM OF VITAMIN D TO


    ACTIVE FORM

    CAUSES BONE RESORPTION


    BONE RESORPTION

    OSTEOBLASTS HAVE PTH RECEPTORS

    INDUCES SYNTHESIS OF PROTEINS WHICH CAUSE


    DIFFERENTIATION OF OSTEOCLASTIC PRECURSORS TO BECOME
    FUNCTIONING OSTEOCLASTS.

    INCREASED OSTEOCLASTIC ACTIVITY


    HYPERPARATHYROIDISM

    PRIMARY SECONDARY TERTIARY

    HYPERPLASIA OF PHYSIOLOGICAL LONG TERM


    PARATHYROID CELLS STIMULATION OF PHYSIOLOGICAL
    LEADING TO PARATHYROID DUE TO STIMULATION LEADING
    HYPERSECRETION HYPOCALCEMIA TO HYPERPLASIA

    VITAMIN D
    ADENOMA
    DEFICIENCY POST RENAL
    CARCINOMA
    RENAL FAILURE TRANSPLANT
    MEN SYNDROMES
    LOW INTAKE
    CALCIUM PTH VITAMIN D PHOPHATE

    PRIMARY

    SECONDARY

    TERTIARY
    TREATMENT
    PARATHYROIDECTOMY

    FLUIDS

    BISPHOPHONATES

    CALCIMIMETICS

    VITAMIN D

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