A RARE CASE: ANTERIOR MEDIASTINAL

NONKERATINIZING SQUAMOUS CELL CARSINOMA OF THE THYMUS

(TYPE C THYMOMA)
Rizki ROMADANI , Indra YOVI , Indi ESHA , Hariadi HATTA , Ina RANGKUTI
1 1 1 2 3

1
Department of Pulmonology and Respirology Medicine, Medical Faculty University of Riau
2
Department of Thoracic and Cardiovascular Surgery, Medical Faculty University of Riau
3
Department of Anatomical Pathology, Medical Faculty University of Riau

INTRODUCTION
• Nonkeratinizing squamous cell carsinoma of thymus (type c thymoma) derived from thymic epithelial cells is a
rare case but mostly aggressive, easily metastasized cancer with very poor prognosis.
• The incidence of type c thymoma is 0.06% of all thymic neoplasms.
• The therapeutic modality is multidisciplinary treatment such as surgery, chemotherapy and radiotherapy.

CASE REPORT
Tn P
A 47-year-old male hospitalized at Arifin Achmad General Hospital. 47 yo
Complained of breathlessness for a week before admitted to
hospital, right chest pain, swollen of the neck and right hand for a
month. Mass found at region lymph node at colli dextra size 7x4x2
cm soft consistency and no pain. His blood counts leukocytosis and
increased of tumor marker test (CEA). From the Bronchoscopy
found encouragement at the main right bronchus. CT scan revealed
solid inhomogenous mass at anterior mediastinal, invasion to
sternum and superior vena cava. Histopathological result from core
needle biopsy is nonkeratinizing squamous cell carsinoma of the
Thymus. The patient received radiation therapy and systemic
chemotherapy by using carboplatin and paclitaxel regiments but
exploratory thoracotomy was not performed.

DISSCUSION
Diagnosis of type c thymoma is ultimately made by histology from core needle biopsy. Debulking surgery was
not performed because the patient identified at an advanced stage.

Histopathological Result
shows solid sheets of atypical epithelioid cells,
necrosis nuclear enlargement with size variation,
hyperchromasia and frequent mitotic figures.

CONCLUSION REFERENCES

Type c thymoma requires special attention because it is
mostly found at an advanced stage.
1. El-Naggar: WHO Classification of head and Neck Tumours, 4th Edition,
2017, Semin Diagn Pathol 2015; 32: 54)
2. Bennisler L. Respiratory system. In: Gray’s anatomy. Williams PL, Bennisler
L, Berry LH, Collins P, Dyson M,et al. Editors. 38 th ed, Churchill Livingstone,
Edinburgh, 1999.p. 1627-76