CLOUD

COMPANY

WELCOME!
Have A Nice Day!
Click To Change Your Subtittle

CLOUD
COMPANY WWW.CLOUDCOMPANY.COM 1
Mechanism of resistance Genetic mechanisms Antimicrobials affected

A. Antimicrobial inactivating (hydrolysing) enzymes

•Amp C Beta-lactamases [Acinetobacter-derived cephalosporinases

(ADCs)] •Chromosomal mediated Insertion sequences ISAba1 and IS1135 •Extended spectrum cephalosporins (including 3rd generation and
increase production of beta-lactamase cephamycin group); cefepime and carbapenems are spared

HOPE YOU LIKE IT!

•Ambler class D OXA-type enzymes
•Chromosomal and Plasmid mediated •Carbapenems
WELCOME TO CLOUD
•Ambler class B metallo–b-lactamases (MBLs), such as VIM and IMP Many slides are waiting for you!
•Mobile genetic elements •Carbapenems

•Ambler class A ESBLs (TEM, SHV)

•Plasmid, chromosomal or mobile genetic elements •All cephalosporins (including 3rd generation) except cephamycin group

B. Reduced access to bacterial targets

•Altered porin channels and other outer membrane proteins Introduction

•Point mutations •Carbapenems
Click To Change Your Subtittle
C. Mutations that change targets or cellular functions

•DNA topoisomerase mutations

•Point mutations in the bacterial targets gyrA and parC topoisomerase •Quinolones
enzymes

•Aminoglycoside-modifying enzyme Introduction 1 Introduction 2 Introduction 3 Introduction 4

•Plasmid, transposons •Aminoglycosides

•Production of efflux pumps

•Point mutations •Tigecycline, aminoglycosides, quinolones, tetracyclines

•Modification of cell membrane lipopolysccarides

•Point mutations •Colistin
CLOUD
COMPANY WWW.CLOUDCOMPANY.COM 2
Pengobatan MDR Acinetobacter, Karbapenem tetap
pengobatan pilihan utama . Penelitian MYSTIC
ketidaksesuaian imipenem sebagai agen yang lebih kuat,
dibandingkan dengan meropenem, untuk pengobatan infeksi
Acinetobacter MDR,
Click To Change Your Subtittle

Pengobatan XDR dan PDR Acinetobacter spp, polimiksin dan

tigecycline harus digunakan sebagai obat pilihan terakhir
untuk pengobatan infeksi tersebut