Professional Documents
Culture Documents
Sudigdo Sastroasmoro
Research report writing ….
Last job in research activity
All research results should be published, otherwise
publication bias will occur (and it occurs!)
Publish or perish
Publishing is equally important as planning and conducting
the study
New trend: Registration of all RCT with commitment to
publish whatever the results will be
Theses, dissertations are considered unpublished until they
are published in the journal
Why bother?
On the other hand most manuscripts are written by
“one in a life time author”: residents
Many of the manuscripts are prepared by ignoring
“Instructions to authors”
It seems that the seniors do not much involve in
manuscript writing (although they sign the form)
Contributing Editors have not much involve in the
manuscript revision
Burden to copy-Editors, unnecessary delay in
publishing
Publication bias
Investigators tend to submit studies with positive
(statistically significant) than negative results
Editors tend to accept studies with +ve than -ive results
Positive results: submit to international journals
Negative results: submit to local journals
Many -ive results are product of small sample size
Inference by manufacturers!
Literature consists of reports with +ive results
Anatomy of research reports
Title
Byline: Authors & Institutions
Abstract & keywords
Contents: IMRAD
Introduction
Methods
Results
Discussion
Acknowledgments
References
Appendices
IMRAD
Introduction - Why did I start?
Methods - What did I do?
Results - What did I find?
Discussion - What do they mean?
Observation on …
Study on …
Investigation of …
An opening ‘A’, ‘An’, ‘The’
Penelitian tentang …., etc
Short titles
Advertisement?!
Title: Inclusion of design
Implementing Evidence-Based Practice in
Undergraduate Teaching Clinics: A Systematic
Review and Recommendations
SDC – sequence-determines-credit
o First (largest) up till last (smallest)
PCI – percent-contribution-indicated
o Contribution of each author is provided
Abstract
Second most read after Title
Contains IMRAD
Re-establish the topic of the research
Gives the research problem and/or main objective
of the research (this usually comes first)
Indicates the methodology used
Presents the main findings
Presents the main conclusions
Brief and easy to read
No abbreviations or acronyms
Abstract
One-paragraph abstract
Structured abstract -increasingly used;
incl. used by Paediatrica Indonesiana
• Abstract: The objective of this project was to identify an effective methodology of approaching
and implementing evidencebased principles in undergraduate teaching clinics to promote
evidence-based dentistry in future clinical practice. A systematic review was undertaken to
examine evidence-based clinical teaching and faculty continuing education. Research
published from 1996 to 2002 was retrieved by searching several databases and the Internet,
along with conducting hand searches and reviewing bibliographies maintained by faculty
experts. Qualitative checklists for different types of studies were created to evaluate the
literature. Relevant studies were selected if they met all four predetermined essential criteria
and a minimum of two out of three desirable criteria. Systematic reviews were chosen if they
met all five essential criteria. Data from selected articles were extracted, and study quality
was assessed. We found that three systematic reviews and nine original research articles
were deemed methodologically acceptable. Problem-based learning and evidence-based
health care interventions increased student knowledge of medical topics and their ability to
search, evaluate, and appraise medical literature. Dental students in a problem-based
learning curriculum, emphasizing evidence-based practices, scored higher on the NDB I
(National Dentistry Boards, Part I) than students in traditional curricula. While effective
modules in implementing theoretical evidence-based principles exist, very few high-quality
studies are available that examine these principles in dental undergraduate teaching clinics.
No methodologically appropriate studies on the education of faculty in the implementation of
evidence-based principles are available. Some studies promote promising theories and
methodologies of teaching evidence-based care; based on these theories, a comprehensive
model is proposed in this article. Considering the strength of evidence in the reviewed
literature, we concluded that an evidence-based approach to clinical care is effective.
Abstract
• Asymmetric division of adult stem cells generates one self-renewing stem cell
and one differentiating cell, thereby maintaining tissue homeostasis. A decline
in stem cell function has been proposed to contribute to tissue ageing,
although the underlying mechanism is poorly understood. Here we show that
changes in the stem cell orientation with respect to the niche during ageing
contribute to the decline in spermatogenesis in the male germ line of
Drosophila. Throughout the cell cycle, centrosomes in germline stem cells
(GSCs) are oriented within their niche and this ensures asymmetric division.
We found that GSCs containing misoriented centrosomes accumulate with
age and that these GSCs are arrested or delayed in the cell cycle. The cell
cycle arrest is transient, and GSCs appear to re-enter the cell cycle on
correction of centrosome orientation. On the basis of these findings, we
propose that cell cycle arrest associated with centrosome misorientation
functions as a mechanism to ensure asymmetric stem cell division, and that
the inability of stem cells to maintain correct orientation during ageing
contributes to the decline in spermatogenesis. We also show that some of the
misoriented GSCs probably originate from dedifferentiation of spermatogonia.
Structured abstract
BW (grams) n %
>2500 10 33.33%
<2500 20 66.67%
Total 30 100.00%
Correct format
Omit vertical & inner horizontal lines
>2500 60 40
<2500 42 37
Total 102 77
Incorrect format
>2500 60 40
<2500 42 37
Total 102 77
lt s:
e su s
R t ic
a t is
g st
t i n
s e n
P re
Results: Presenting percentages
& numbers
Cholesterol level,
Standard mg/dl
treatment
300 200
mg/dl
n=10000
R Clinical
n=10000
New 300 197
treatment mg/dl
t= df = 9998 p = 0.00002
Statistical
Clinical significance vs. statistical significance
Cured Died
Standard Rx 0 10 (100%)
New Rx 3 7 (70%)
SD, SE
Avoid this format: 50 + 12 mcg/L
May be read: + 1 SD, 2 SD, 1 SE, 2 SE
Preferably:
50 (SD 12) mcg/L
Note: “In our study” is more commonly used than “in our research”
Discussion
Conclusions
Should answer all previously stated
research question(s)
Must be supported by own data
Discussion
Common errors
Answers not previously stated question(s)
Conclusions are not based on own data (e.g.,
based on literature review)
‘Other findings’ are included as conclusions
References
‘Vancouver style’ (see example) vs. ‘Harvard style’
Refer to: ICJME (International Committee of
Medical Journal Editors (last amendment: October
2008)
Abbreviations of Journal’s name: refer to NLM-
NIH
In-house style may modify standard style
Should 100% match between citation numbers in
the text & reference list
Journal articles
Journal article, 6 or less authors:
– Winichagoon P, Fucharoen S, Chen P, Wasi P.
Genetic factors affecting clinical severity in b-
thalassemia syndromes. J Pediatr Hematol Oncol.
2000;22:573-80
Journal article, >6 authors.
– Sogut A, Altin R, Uzun L, Ugur MB, Tomac N,
Acun C, et al. Prevalence of obstructive apnea
syndrome and associated symptoms in 3-11 year-
old Turkish children. Pediatr Pulmonol.
2005;39:251-6.
Books
Book / Monogram:
– Madden R, Hogan T. The definition of disability in
Australia: moving towrds national consistency.
Canberra: Australian Institute of Health and Welfare;
1997. p. 267-73.
Book with edition:
– Renton M. Compendium of good writing. 3rd ed.
Milton: John Wiley & Sons; 2004.
Chapter of the book:
– Blaxter M. Social class and health inequalities. In:
Carter C, Peel J, editors. Equalities and inequalities in
health. London: Academic Press; 1976. p. 369-80.
Others
Thesis or dissertation:
– Wood MA. A study of the perception of the impact of
modeling on the development of commitment to action in
decision conferencing [PhD Thesis]. Perth (WA): Curtin
University of Technology; 2004.
Electronic materials:
– Pettinger R. Global organizations [monograph online].
Oxford: Capston Publishing; 2002 [cited 2004 Sep 28]>
available from: http://www.netlibrary.
Conference Proceeding.
– Hamden P, Joffe JK, Jones WG, editors. Germ cell tumors V.
Proceeding of the 5th Germ Cell Tumor Conference; 2001 Sep
13-15; Leeds, UK. New York: Springer; 2002.
English language
Tenses:
Introduction - Present tense, because it
refers to general truth
Methods - Past tense, because it
addresses completed actions in the past
Results - Past tense
Discussion - Swinging between present &
past, depending on the issue
discussed
English language
Spelling:
‘American English’
anemia vs. anaemia
color vs. colour
randomized vs. randomised
leukocytes vs. leucocytes
Always use spell checker!!!! (easy & very useful)
English language
Effective English vs. wordy expressions
Subject – predicate agreement
Use commonly used phrases or terms, e.g. potassium
- hyperkalemia
sodium - hyponatremia
platelets - thrombocytopenia
Appropriate use of connecting phrases
Punctuations: full stop, comma, colon, semicolon,
brackets are typed without space
Full stop (26.4%) instead of comma (26,4%) for decimal
separation
Use more active than passive voices
• The patients were randomized to either receive
……. or …..
– We randomized the patients to either receive …
• Subjects who had spinal abnormality, those with
history of seizures, or those with chromosomal
abnormality were excluded …
– We excluded subjects with spinal abnormality,
those with history of seizures, …
Crucial!!!
Alignment of
! ! !
se
Title e n
n s
m o
Research Questions / Hypotheses
o m
e c Methods
Us Conclusions
Crucial!!!
Read carefully
“Instructions to authors”
word by word!!
Use check-list!!
Importantl!!!
Read and re-read,
Revise and re-revise,
Ask all authors to read
Ask other colleagues to read
Keep the manuscript in your drawer for a few days
Read and re-read
Revise and re-revise
Make sure that all meet journal requirements
Before asking your secretary
to send the manuscript!!!
Brief and clear: brevity and clarity is a must
Avoid jargons!!:
– a considerable amount of - much
– absolutely essential - essential
– as a consequence of - because
– at an earlier date - previously
– at this point of time - now
– despite the fact that - although
– for the purpose of - for
– in a satisfactory manner - satisfactorily
– new initiatives - initiatives
For theses or dissertations: reasonably much
more pages than journal format, but “the
thicker the better” is wrong, dead wrong
Huth: Most >150-page long theses pages
usually have only 50 pages that scientifically
needed
Important concepts in life are usually expressed in short
words:
• hidup - mati • life - death
• siang - malam • Day - night
• cinta - benci • love - hate
• sehat - sakit • healthy - sick
• susah - senang • sad - joy
• lapar - kenyang • hungry - full
• kaya - miskin • rich - poor
• gelap - terang • dark - bright
Guidelines for reporting (ICMJE)
Clinical Trials: CONSORT – Consolidated
Standard for Reporting Trials
Diagnostic studies: STARD – Statement for Reporting
Diagnostic Accuracy Studies
Prognostic studies: REMARK
Etiological studies: STROBE
Meta-analysis:
Trials: QUOROM (1999)
Non-exp studies: MOOSE (2000)
Meta & SR PRISMA (Preferred Reporting Items
for Systematic Review and Meta-
analyses)