MSDS

1
 MSDS Contents

• Hazardous Ingredients • Product Information

• Preparation Information • Physical Data
• Fire & Explosion Hazard • Reactivity Data
• Toxicological Properties • Preventative Measures
• First Aid Measures

2
 Hazardous Ingredients

• Chemical Identity • Concentration

• CAS Number • PIN Number

• LD50 Species and

Route

• LC50 Species and

Route

3
 toxic (T)

flammable (F) explosive (E) .

irritating (Xi) or harmful (Xn)

corrosive (C) oxidizing (O)

4
environmentally dangerous
 Label Bahan
TOLUENE
PRODUCTSULFONIC
IDENTIFIER
ACID
RISK PHRASES:
Highly irritating to skin, eyes, and nose
HEALTH HAZARD DATA:
Supplier
ABC Chemicals
123 Chemical Drive
Strong Acid: Treat as sulphuric acid Chemical City
EFFECTS OF OVEREXPOSURE: ACUTE
PRECAUTIONARY MEASURES:
identifier
1-800-CHE-MICAL
PERSONAL PROTECTIVE EQUIPMENT
EYE: Face shield and goggles
GLOVES: Rubber
OTHER CLOTHING AND EQUIPMENT:
Rubber apron, rubber boots

FIRST AID:
EYES: Flush with water for 15 minutes. Consult
with physician
Refer to Material Safety
SKIN: Flush with water as per sulphuric acid Data Sheet
INGESTION: Treat as per sulphuric acid. Consult
with physician FRANCAIS AU VERSO

5
CONTOH PENGELOLAAN

PRODUCT
MethylIDENTIFIER
Alcohol
Precautions:
Use in well ventilated
area
Avoid contact with skin
and eyes
Keep away from spark
and flame
Refer to Material Safety
Data Sheet

6
Compressed Gas
Precautions
Transport and handle
with care
Make sure cylinders are
properly secured
Store away from
sources of heat or fire
Use proper regulator

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Compressed Gas
Characteristics
 Gas inside cylinder is
under pressure
 The cylinder may
explode if heated or
damaged
 Sudden release of high
pressure gas streams
may puncture skin and
cause fatal embolism

8
Oxidizing Material
Precautions
Store away from Class
B (flammable and
combustible) materials
Store away from
sources of heat and
ignition
Wear the
recommended protective
equipment and clothing

9
 Workplace Labels
in Research Labs
• Product identifier
(name)
• MSDS must be
available
Agent
Green

10
Materials Causing Immediate
and Serious Toxic Effects

Precautions
Avoid inhaling gas or vapours
Avoid skin and eye contact
Wear the recommended
protective equipment and
clothing
Do not eat, drink or smoke
near these materials
Wash hands after handling
11
Dangerously Reactive Material
Characteristics

Store away from heat

Avoid shock and friction
Wear the recommended
protective equipment and
clothing

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 Klassifikasi Pengelolaan B3

Klas A Klas D
Klas B Klas E
Klas C Klas F

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 Label di Tempat Kerja

• Identifikasi Produk
• Safe Handling Precautions
• Referensi pada MSDS

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 MSDS Contents

• Hazardous Ingredients • Product Information

• Preparation Information • Physical Data
• Fire & Explosion Hazard • Reactivity Data
• Toxicological Properties • Preventative Measures
• First Aid Measures

15
Class A

• Compressed Gas
– Any Hazardous Material that is contained
under pressure including compressed gas,
dissolved gas, or liquefied gas

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Compressed Gas Cylinders

• store and transport with safety cap

• comply with storage restrictions
• DO NOT store fuel gas with oxygen
• secure in an upright position
• use in a well ventilated area
• use the proper type of regulator and know its history

17
Class B

• Flammable and Combustible Material

– Flammable Gases
– Flammable and Combustible Liquids
– Flammable Solids
– Flammable Aerosols
– Reactive Flammable Material

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Flammable Materials

• Methanol, Toluene, Butane, Ethanol

• Store liquids in Flammable Storage Cabinet
• Store minimum quantities in lab
• Explosion-proof fixtures required
• Decant in large quantities in fume hood
• NEVER store with oxidizers
• Keep away from heat, ignition sources, and direct sunlight
• Use static lines when transferring
• Refrigerator must meet NFPA Standard 56C ( Flammable Material Storage Units)

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Class C

• Oxidizing Material
– Any Hazardous Material which causes or
contributes to the combustion of another
material by giving oxygen or some other
oxidizing substance, whether or not it is
combustible.
– Organic Peroxides

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 Oxidizers

• Chlorates, Nitric Acid, Peroxides, Permanganates,

Perchlorates, Nitrites, Nitrates
• Easily oxidize metal powders, organic materials
• Keep minimum quantities in lab
• Segregate from other materials, such as organic solvents
• Use a glass-heating mantle or sand bath to heat material
• PPE and/or Explosion barriers may be require

21
 Perchloric Acid

• Perchlorate salts are explosive

• Use a perchloric acid fume hood
• Wash down fume hood after use
• Never store with organic chemicals especially
alcohols and glycerol
• Store in a ceramic tray
22
 Organic Peroxides

• Some are very unstable

• Sensitive to heat, friction, impact, sparks, light
• Use minimum quantities in lab
• NEVER replace unused peroxides into original
container
• NEVER use a metal spatula to handle peroxides
• Refrigerate to minimize decomposition

23
 Peroxide Formers

• Have caused several severe laboratory

explosions
• Contributing Factors: Oxygen, Light, Storage
Time
• Visual Identifiers: Crystals, Floating wisp-like
structures
• Date and Dispose of within 1 year

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 Common Chemicals forming
Peroxides

• Diethyl ether
• Tetrahydrofuran
• Dioxane
• Methyl isobutyl ketone

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Class D1

• Poisonous & Infectious Materials

– Material causing immediate and serious toxic
effects
– Materials which are potentially fatal or may
cause permanent damage if inhaled,
swallowed, or absorbed through the skin, or
may burn the skin or eyes upon contact

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Class D2

• Poisonous & Infectious Materials

– Material causing other chronic or long term
effects
– Material which may cause dealth or permanent
damage as a result of repeated exposure over
an extended period of time; may be an irritant
to the skin, eyes, or respiratory system; may
cause cancer, birth defects, or sterility.

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Class D3

• Poisonous & Infectious Materials

– Biohazardous and Infectious Materials
– Materials which may cause disease in
humans and animals, such as viruses,
bacteria, and fungi; may also include
cultures and diagnostic specimens such as
blood, urine, and body tissue.

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Class E

• Corrosive Material
– Material which may corrode aluminum and
steel or human flesh
– Material which are anhydrous corrosive
gases

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 Inorganic Acids

• Sulfuric Acid, Nitric Acid, Perchloric Acid, Hydrochloric

Acid
• Segregate from bases and organic compounds
• Store in a ventilated acid cabinet
• Know the location of eye washes and safety showers
• Use a safety carriers
• Store on lower shelves

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 Bases

• Sodium hydroxide, Ammonium hydroxide

• Segregate from acids and organic compounds
• Store in a ventilated cabinet
• Know the location of eye washes and safety showers
• Use a safety carrier
• Store on lower shelves

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 Hydrogen fluoride

• Is extremely corrosive
• Dissolves glass
• Absence of immediate pain, penetration
can be extensive, leading to serious injury
or death
• Causes severe eye irritation and skin burns
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Class F

• Dangerously Reactive Material

– Materials which undergo vigorous
polymerization, decomposition, or condensation
– Materials which become self-reactive under
conditions of shock, or increased temperature
or pressure
– Materials which react vigorously with water to
produce a very toxic gas

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Ethylene Oxide

• Used as a Sterilant at hospital

• Extremely flammable
• Supplies its own oxygen/Chemically decomposes
• Highly Reactive
• Very Corrosive
• Human Carcinogen

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Water Reactive Materials

••Sodium
Sodium metal,
metal, acid
acid and
and metal
metal
anhydrides,
anhydrides, calcium,
calcium, phosphorous
phosphorous
pentachloride,
pentachloride, aluminum
aluminum chloride-
chloride-
anhydrous
anhydrous
••Special
Special storage
storage requirements
requirements
 Pyrophoric Materials

••Air
Air reactive
reactive
••White
White phosphorus,
phosphorus, diborane,
diborane, diethyl
diethyl
aluminum
aluminum chloride,
chloride, lithium
lithium
••Store
Store under
under anan inert
inert atmosphere
atmosphere
such
such as
as nitrogen
nitrogen
 Cryogenic Materials

••Liquid
LiquidNitrogen
Nitrogen
••Never
Never useuseto
tocool
coolsubstances
substanceswhich
whichare
arecombustible
combustible
in
inair
air-- explosion
explosionrisk
riskfrom
fromcondensation
condensationof
ofoxygen
oxygen
from
fromair
air
••Use
Useinsulated
insulatedgloves
glovesand
andface
faceshield
shield
••Keep
Keepcryogenic
cryogenicsubstances
substancesin
incontainers
containerswhich
whichare
are
not
nottightly
tightlyclosed
closedto
toprevent
preventexplosive
explosivepressure
pressurebuild-
build-
up
up
••Use
Useonly
only equipment
equipmentdesigned
designedfor
forcryogenic
cryogenic materials
materials
 General Dry Chemicals

••Relatively
Relatively innocuous
innocuous or
or unreactive
unreactive
••No
No special
special storage
storage requirements
requirements
 Chemical Compatibility
• Never store incompatible materials
together
• Vapours will react
• Chemical Compatibility Chart

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 Supplier Label

• Product Identifier
• Hazard Symbols
• Border
• Bilingual
• Risk Phrases and Precautions
• First Aid, Supplier Information
• Precautions
• Safe Handling Precautions
• Reference to MSDS

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 Laboratory Labels
• No Supplier Label Required:
– If Controlled Product
• originates from lab supply house
• intended solely for lab use
• package quantity is less than 10 kgs
– If Package Label contains
• product identifier
• statement indicating MSDS available
• risk phrases/precautionary measures
• first aid measures

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 Laboratory Samples
• No Supplier Label Required:
– If the Controlled Product
• container is less than 10 kgs
• intended for lab analysis
– If supplier provides a label containing
• product and/or chemical identifier
• supplier identifier
• statement “Hazardous Laboratory Sample for hazard
information or in an emergency call” plus emergency
phone number

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 Workplace Label

• Product Identifier
• Safe Handling Precautions
• Reference to MSDS

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 Workplace Label Uses

• Transfer of material from a Supplier Labelled

container to another container
• Replacement of a damaged Supplier Label

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NFPA Hazard Classifications

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Laboratory Samples

• No Supplier or Workplace Label Required

– If controlled product is:
• produced in workplace
• originates from lab supply house
• intended solely for lab use
• product and/or chemical identifier
• “Hazardous Laboratory Sample” statement which
includes an emergency phone number

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 MSDS Contents

• Hazardous Ingredients • Product Information

• Preparation Information • Physical Data
• Fire & Explosion Hazard • Reactivity Data
• Toxicological Properties • Preventative Measures
• First Aid Measures

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 Hazardous Ingredients

• Chemical Identity • Concentration

• CAS Number • PIN Number
• LD50 Species and
Route
• LC50 Species and
Route

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 Product Information

• Product Identifier
• Manufacturer’s/Supplier’s Name and
Address
• Emergency Telephone Number
• Product Use

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 Preparation Information

• Prepared by (Group, Department, etc.)

• Phone Number
• Date of Preparation

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 Physical Data

• Odour Threshold • Physical State

• Vapour Pressure • Odour & Appearance

• Coefficient of Water/Oil • Specific Gravity (Water=1)

Distribution
• Vapour Density (Air=1)
• Boiling Point (oC) and • pH
Freezing Point (oC)
• Percent Volatile (by
• Evaporation Rate (Butyl volume)
Acetate=1)

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 Fire & Explosion Hazard
• Conditions of Flammability
• Means of Extinction
• Sensitivity to Mechanical Impact
• Sensitivity to Static Discharge
• Flashpoint (oC) and Method
• Upper and Lower Flammable Limits (%)
• Autoignition Temperature (oC)
• Hazardous Combustion Products

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Class A Fires

• Are fires fueled by materials that, when

they burn, leave a residue in the form of
ash
• Paper, wood, cloth, rubber, and certain
plastics
• Extinguisher type: Water, Dry Chemical

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Class B Fires

• Fires which involve flammable liquids and

gases
• Gasoline, paint thinner, grease, propane,
acetylene
• Extinguisher type: Carbon Dioxide, Dry
Chemical

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Class C Fires

• Fires that involve energized electrical

wiring or equipment (motors, computers,
electrical panels). Note once the power
has been cut, a Class CF fire becomes
one of the other classes
• Extinguisher type: Carbon Dioxide, Dry
Chemical
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Class D Fires

• Class D fires involve exotic metals, such

as magnesium, sodium, titanium, and
certain organometallic compounds such
as alkyllithium and Grignard reagents

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 Reactivity Data
• Stability
• Incompatible Materials
• Conditions of Reactivity
• Hazardous Decomposition Products

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 Toxicological Properties

• Irritancy to Product • Routes of Entry

• Effects of Acute • Exposure Limits
Exposure
• Synergistic Products
• Evidence of
Carcinogenicity, • Sensitivity to Product
Reproductive Toxicity,
• Effects of Chronic
Teratogenicity or
Mutagenicity Exposure

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 Preventative Measures
• Personal Protective Equipment
• Engineering Controls
• Spill and Leak Procedures
• Waste Disposal
• Handling Procedures and Equipment
• Storage Requirements
• Special Shipping Information

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 When a Spill Strikes

• 1) Assess the risk

– Minor Spill, handled by personnel within lab or department
– Major Spill, isolate area, Declare a Code Brown, HAZMAT
Team required
– Provide HAZMAT Team with MSDS for spilled material,
quantity spilled

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 When a Spill Strikes

• 2) Select personal protective equipment

– consult MSDS and other literature sources

• 3) Confine the spill

– Speed Counts
– Limit the spill area by blocking, diverting, or confining spill
– Use absorbents, tiger tails, drain plugs, dikes

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 When a Spill Strikes

• 4) Stop the Source

• 5) Evaluate the Incident & Implement
Clean-up
– Used absorbents should be considered
hazardous waste

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 When a Spill Strikes

• 6) Decontaminate
– Decontaminate site, personnel, & equipment
by removing or neutralizing the hazardous
materials

• 7) Complete Incident Report

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 First Aid Measures

• Inhalation • Ingestion
• Eye Contact • Skin Contact

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 Additional Information
• MSDS’s Must be Readily Available
• 3 Year Expiry Date
• New Information becomes Available

65
 MSDS Standardization
• International Organization for
Standardization (ISO)
• American National Standards Institute
(ANSI)
• International Labour Organization (ILO)
• European Union (EU)

66
 WHMIS II
• Proposed Modifications and/or Changes to
Current WHMIS laws
• Exempt categories may be required to
follow labeling and MSDS requirements,
such as Consumer Products, Explosives, and
Pest Control Products
• No official changes to WHMIS laws have
occurred
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 Worker Education
• Generic
• Site Specific
• Annual Review

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Occupational Hygiene

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Routes of Entry
• Inhalation
• Skin Absorption
• Injection
• Ingestion

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Physical Forms
• Dust
• Mist
• Fume
• Vapour
• Gas

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 Action of Toxins
• Acute Effects
• Chronic Effects
• Latency Period of Disease
• Sensitizers

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 Dose-Response Relationship
• Effect is Directly Related to Dose
• No Effect Level

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Basis for Exposure Standards
• Chemical Analogy
• Animal Experimentation
• Human Epidemiological Data

74
 Occupational Exposure
Standards
• Guidelines
• ACGIH, Occupational Health and Safety Act
• Threshold Limit Value (TLV)
• Short-term Exposure Limit (STEL)
• Ceiling

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 Methods of Control
• Engineering Controls
• Administrative Controls
• Personal Protective Equipment

76
 Engineering Controls
• Elimination
• Substitution
• Local Exhaust Ventilation
• General Ventilation
• Isolation
• Preventative Maintenance
77
 Personal Protective
Equipment
• Respirators, Gloves, Eye Protection, etc.
• The Human Factor
• Training Essential

78
 Emergency Planning
• Moral Reasons - Good Corporate Citizen
• Legal Reasons - Legislation/Court Action
• Economic Reasons - $$$$$$$$

79
 Objectives
• Prevent Death & Injury
• Reduce Damage to Plant and Equipment
• Get Back to Business ASAP

80
 Emergency Planning
• Analysis
• Procedures
• Evacuation Plan
• First Aid Treatment
• Exercises and Drills

81
Inventory

• Annual Update and Review Required

• Feb 1st Compliance Date

82
Duties and Responsibilities

• Departmental Supervisor and/or Manager

– Responsible for WHMIS System within
Department
– Provide Departmental WHMIS Trainer
– Facilitate Training
– Ensure Departmental Trainer fulfils their
duties

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Duties and Responsibilities

• Departmental WHMIS Trainer

– Departmental Inventory
– Departmental WHMIS Training
– Training Records
– Ensure proper labeling is used
– Maintain Departmental WHMIS Manual

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