PATHOPHYSIOLOGY

3. Present the pathophysiology of

the patient’s condition leading to
Multiple Organ Failure basing
on the situation. Present this in a
diagram and discuss thereafter.
• Thermoregulation is controlled by the hypothalamus which uses sensory
cells to detect the temperature of circulating blood and the cutaneous
tissue. The body responds to a rise in temperature by initiating cooling
methods which take the form of conduction, convection, evaporation,
and radiation.
 PATIENT

He experienced occasional nose

Jonas, 25 years old, Male bleeds and non-specific papular
rash

Active and robust as he trains No blood or muscular

himself for the marathon disorders
 Pathophysiology of MODS based on the Case Scenario

Extensive Physical Exertion

and Heatstroke

↑ Core Temperature

↑ Muscle Blood Flow ↑ Skin Blood Flow ↓ Gut Blood Flow

 ↑ Muscle Blood Flow ↑ Skin Blood Flow

↑Cardiovascular strain

90/50
mmHg
Hypotension ↓Heat Loss

↓ Cerebral blood flow Heat Storage

Cells Heated >40°C 40°C

↑ Brain Temperature
 Brain Damage/Injury
Vascular Endothelium
Damage

COLLAPSE

Loss of Coagulation
consciousness Microvascular Thrombosis
Consumptive Coagulation
 ↓ Gut Blood Flow

Ischemia
Nitrosative/Oxidative Stress
Coagulation
Microvascular Thrombosis
Consumptive Coagulation
↑Gut Epithelial Membrane
Permeability

Endotoxin Leakage

Innate Immune System

MULTI-ORGAN
Adaptive Immune System SYSTEM
SIRS FAILURE
Cytokines, Soluble Cytokine Receptors
That’s all ~
Thank You!