Disfungsi Endotel and

Atherosklerosis
Kuliah Blok 17
Tujuan

 Memahami fungsi endothelium

 Memahami proses terjadinya disfungsi endotel
 Memahami proses terjadinya aterosklerosis
Referensi

 Guyton and Hall. Medical Physiology.

 Vanders Human Physiology.
 One of the most fundamental principles of
circulatory function is the ability of each tissue
to control its own local blood flow in proportion
to its metabolic needs.
What are the specific needs of the
tissues for blood flow?

Delivery of oxygen to the tissues

Delivery of other nutrients, such as glucose, amino

acids, and fatty acids

Removal of carbon dioxide from the tissues

Removal of hydrogen ions from the tissues

Maintenance of proper concentrations of other ions

in the tissues
. Transport of various hormones and other
substances to the different tissues
 Vasodilator theory in blood flow regulation

 Vasodilators: Adenosine, CO2, lactic acid, ADP, Histamine, ion Kalium,

ion Hydrogen

TISSUE RELEASE OF
METABOLISM VASODILATORS

RESISTANCE IN
ARTERIOLE

BLOOD
FLOW
Oxygen demand theory in blood flow
regulation

TISSUE METABOLISM OXYGEN

or CONCENTRATION IN
OXYGEN DELIVERY TO TISSUES
TISSUES

RESISTANCE
OF ARTERIOL

BLOOD
FLOW
Ikhlas M Jenie, Budi Mulyono, Soejono Aswin, Sri Kadarsih Soejono. High Glucose, but Not
Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells. International
Journal of Public Helath Science, Vol.4 No.3, September 2015.
Ikhlas M Jenie, Budi Mulyono, Soejono Aswin, Sri Kadarsih Soejono. High Glucose, but Not
Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells. International
Journal of Public Helath Science, Vol.4 No.3, September 2015.
 Hypotheses of Atherogenesis

The response-to-injury

The response-to-retention

Oxidative modification
The response-to-injury hypotheses
The response-to-retention hypothesis
The oxidative modification hypothesis
Ikhlas Muhammad Jenie, Rizki Afrian, Barii Hafidz Pramono,
Captopril Mencegah Stres Oksidatif pada Tikus Wistar Jantan
dengan Diet Tinggi Lemak. Mutiara Medika Vol. 16 No. 1: 8-14,
Januari 2016
 TERIMA KASIH
&
WASSALAMU’ALAIKUM WR.WB