Lecture No.

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Oxidation and ketone body biosynthesis

• At the end of this lecture, student will be able to

– Explain different stages of lipid catabolism

– Describe the biochemical reactions in fatty acid
biosynthesis
– Differentiate ketogenesis and ketolysis

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 β Oxidation of Fatty acids

• Activation of fatty acid

• Transport of fatty acid into mitochondria
• β oxidation proper

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 Activation of fatty acid

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 Transport of fatty acid into mitochondria

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 β oxidation
proper

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 Energetics

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 Summary

• Beta oxidation occurred in mitochondria

• Major source of energy
• acetoacetate and beta-hydroxybutyrate can be
reconverted to acetyl-CoA to produce energy, via the
citric acid cycle
• The heart preferentially utilizes fatty acids for energy
under normal physiologic conditions

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