Professional Documents
Culture Documents
PHARMACODYNAMICS
What drugs do to the body
Biological activity of the drug
Concerned with:
Depress CNS-Anaesthetics
Replacement
Endogenous/Exogenous Substances
(Insulin/Vitamin)
Chemotherapy
Induction
Inhibition
Action through Ion channels
Action by Replacement
Chemotherapy
TARGETS OF DRUG ACTION
Receptors
Ion channels
Enzymes
Carrier Molecules
RECEPTORS
Receptors and Receptor binding (Specificity and affinity)
Signaling mechanism(Transducer Mechanism)
Affinity
Drug occupancy
Various Response:
Agonist (Affinity-Intrinsic Activity)
Antagonist (Affinity-No Intrinsic Activity)
Partial Antagonist (Affinity-Low Intrinsic Activity)
Inverse Agonist (Affinity-Opposite Intrinsic Activity)
RECEPTORS
Partial Agonists
Low Efficacy
Receptor Occupancy and Response
Antimicrobial action