Coagulation Profile

•Coagulation profile is done to determine proper

concentrations of coagulation factors in the
blood.
•This test includes two tests, namely, Activated
Partial Thromboplastin Time test and
Prothrombin Time test. 
Purpose of a coagulation test

 liver disease
 thrombophilia, which is excessive clotting
 hemophilia, which is an inability to clot
normally
 Coagulation tests are useful in monitoring people
who take medications that affect clotting ability.
 Purpose of a coagulation test

 In case of excessive unexplained bleeding

 In case of easy bruising
 In acute conditions such as Disseminated
intravascular coagulation
 In chronic conditions such as liver disease
 Before surgery
 Prothrombin time .
•Prothrombin is a protein which is produced by the liver.
Prothrombin time determines the time blood will take to
clot.
•The Prothrombin time increases in case the patient is on
blood-thinning medications or has hemophilia or liver
disease. Malabsorption of the prothrombin protein may
also affect the results of prothrombin time.
• This test is also done in patients who are taking medicines
that affect the clotting time such as warfarin. 
 partial thromboplastin time (ptt)
• test helps to determine the ability of a person
to form blood clots appropriately.
• The aPTT test measures the number of
seconds taken by a clot to form in a sample of
blood after the addition of reagents. This test
assesses the amount and function of clotting
factors.
 Bleeding time

•This test analyzes how quickly small blood

vessels close up and stop bleeding. It’s
performed differently than the other blood
tests.
International Normalized Ratio (INR)

is calculated as a ratio of the patient’s PT to a•

control PT standardized for the potency
of the thromboplastin reagent developed by
the World Health Organization (WHO) using the
:following formula
INR = Patient PT ÷ Control PT 