Dermatovenereology Departement

Medical Faculty of Sebelas Maret University

Dr. Moewardi General Hospital, Surakarta

Research Report

THE CORRELATION OF CD4 LEVEL WITH CONDYLOMA ACUMINATA

IN DR. MOEWARDI GENERAL H OSPITAL SURAKARTA

Elok Nurfaiqoh
Dr. dr. M.Eko Irawanto, Sp.KK (K)

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INTRODUCTION

Human
Transmitted through
immunodeficiency
blood and body fluid
virus is lentivirus

HIV replication 
CD4 level in early
destruction of
infection : 200-350
lymphocytes cluster of cells/ul
differentiation (CD) 4
2
INTRODUCTION

Condyloma acuminata (CA)

Caused by The most
Human Infect common
Papilloma Virus mucocutaneous causative virus:
(HPV) type 6 and 11

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OBJECTIVES

To investigate the correlation between CD4 level

and CA

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METHODS

Study design : Retrospective study, cross sectional

Subjects : HIV patients with and without condyloma accuminata
(medical record data inpatient and outpatient DV)
Place : Dr. Moewardi General Hospital Surakarta
Time : 1st March 2016 – 1st March 2021
Statistical Analysis : Chi Square, SPSS IBM version 22 (p<0.05=
significant)
Ethics : Approved by Health Research Ethical Committee of Dr.
Moewardi General Hospital

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METHODS

Inclusion criteria

• HIV patients (with or without CA)

• Complete medical record (CD4 level)

Exclusion criteria

• No CD4 level examination

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METHODS
HIV Patient

Inclusion& exclusion criteria

Without CA
CA

≥200
cell/ul < 200 cell/ul ≥200 cell/ul < 200 cell/ul

Statistical Analysis 7
RESULTS

Sex

29% Male

71%

8
RESULTS

Education

Post graduated1

S1 5

Diploma 8

Senior high school 53

Junior high school 11

Primary School 11

No School 3
0 10 20 30 40 50 60

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 RESULTS

Occupation

45

8 7 6 9 8
Unemployment Student Civil servant Employee Enterpreneur Housewife

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RESULTS

83 Patients

CA Without CA

≥200 cell/ul 18 24

< 200 cell/ul 27 14

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RESULTS

Score p

Pearson chi square 4,420a 0.036

Correlation 0.225
coefficient

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DISCUSSIONS

HIV patients have

Immunocompromised
low CD4 level

Cd4 level: to predict

Opportunistic
progression
infection (CA)
synptomps
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DISCUSSIONS

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DISCUSSIONS

• HPV  condyloma acuminata: manifest as

verrucous papules especially on genital area

• Risk factors: multiple partner, MSM, unprotected

sex, immunocompromise and immunologic factor

• Imunocompromise  increase accuisition,

progression and persintace of HPV infection

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DISCUSSIONS

• CD4 < 200 cell/ul : 49.4%

This study • CD4 ≥ 200 cell/ul: 50.6%
• p=0.036

• Relationship between CD4 level and

Li Yu et al CA (CD4< 200 cell/ul)

• CA in HIV patients : mean CD4 level

Nnoruka et al of 67.2±0.38

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DISCUSSIONS

Infection HIV relates with oncogenic HPV infection

Denny et al, 2015: HIV patients have high prevalence of

HPV infection, persistent HPV infection and cervix
cancer

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DISCUSSIONS

Limitations

Single center study Small sample size

Incomplete medical
record data

18
CONCLUSION

• CD4 level significantly correlates with CA

• Its correlation coefficient is low

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THANK YOU

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21
DISCUSSIONS

Verma M, Erwin S, Abedi V, et al. Modeling the mechanisms by which HIV associated immunosuppression influences HPV 22
persistence at the oral mucosa. PLoS One. 2017; 12(1): 1-20
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