B.

PHARMACY VII SEMESTER

PRACTICE SCHOOL REPORT

DEPARTMENT OF DRUG STORE MANAGEMENT &

INVENTORY CONTROL G D MEMORIAL COLLEGE
OF PHARMACY
 DECLARATION
This is to certify that the present work is carried out by
RAM RATAN ( 788943 )
In the department of drug store management & inventory control,
for the completion of practice School.

HEAD OF DEPARTMENT PRINCIPLE

 Chronopharmacology
INTRODUCTION :-

Chronology :-
The arrangement of events according to the time of
occurrence .Rhythm

CHRONOBIOLOGY :-
 The science dealing with the phenomenon of rhythm city in
living organisms
 In medicine, 3 disciplines take into account the influence of
time:
I. CHRONOPHYSIOLOGY
II. CHRONOPATHOLOGY
III. CHRONOPHARMACOLOGY
Definition:-
 The study of rhythmic, predictable-in-time differences in the
effects and/or pharmacokinetics of drugs both in experimental
animals and in men. It investigates the effects/side effects of drugs
upon temporal changes in biological functions or symptoms of a
disease as well as drug effects as a function of biologic timing.

Chronopharmacology:-
 Investigative science concerned with the biological rhythm
dependencies of medications.
 In case of Chronopharmacology it divides it to three in
subtypes.
a) Chronophysiology
b) Chronopathology
c) Chronopharmacology
Chrono pharmacology further deals with:-

Chrono
therapeutics

Chron esthesy Chrono

kinetics

Chrono
pharmacology

Chrono
Chronergy toxicology

Fig. 1: Chronopharmacology and its disciplines.

Mechanism of Circadian Rhythms
•Circadian clock present in brain coordinates daily physiological cycle
like
● Sleep wake cycle
●Digestion and temperature
● Hormones

•Biological Rhythms Observed in Various Biological Systems :-

1. Urinary system :-
2. Gastrointestinal system :-
3. Hepatic system :-
4. Cardiovascular system :-
5. Hormones :-
 Diseases exhibiting Circadian Rhythm
 Allergic Rhinitis
 Bronchial asthma
 Arthritis
 Angina pectoris and Myocardial infarction
 Peptic ulcer disease

DRUGS UNDERGOING CHRONOKINETCS :-

• Antibiotics :-
• Amino glycosides
• Cephalosporins
• Ampicillin
• Anti hypertensive drugs :-
• propanolol
• verapamil
 •Anti inflammatory drugs :-
• Indomethacin
• Ketoprofen.
•Anti migrane drugs :-
• Samaritan
•Anti cancer drugs :-
• 5 fluorouracil

• Opioid analgesics:-
•tramadol
•Morphine

•Heparin
 •Local anesthetics:-
•lidocane
•mepivacaine
•betoxycaine
•General anesthetics:-
•Barbiturates
•Pentobarbital.
•Anti psychotic drugs:-
•Chlorpromazine
•Chronotherapeutics is found to be useful in –
• Allergic rhinitis
• Bronchial asthma
• Peptic ulcer disease
• Arthritis
• Cardio vascular disorders
• Diabetes mellitus
• Oral contraceptives
• Cancer
THANK YOU