Calcium Channel

Blocker Medications
Presented and Prepared by: Marriette B. Antiquina

Submitted to: Ourem Loren Z. Casinto, RN

 What is Calcium Channel Blocker?
• Calcium channel blockers block the small pores in cells (called L-type calcium channels) that
allow calcium to move in and out, and widen blood vessels as well as affect the activity of nerve
cells.
• Calcium channel blockers are typically used to treat high blood pressure or heart problems.
Some have also been studied experimentally to treat mania or depression in bipolar disorder.
Types of Calcium Channel
Blocker Medications
01 02
Dihydropyridines Phenylalkelamines
a group of medications that group of medications
block calcium channels relatively selective for
located in the muscle cells of myocardium, reduce
the heart and arterial blood myocardial oxygen
vessels, thereby reducing the demand and reverse
entry of calcium ions into the coronary vasospasm, and
cell. are often used to treat
angina.
Types of Calcium Channel
Blocker Medications
03
Benzodiazepines
depressants that produce
sedation and hypnosis,
relieve anxiety and muscle
spasms, and reduce seizures.
CALCIUM CHANNEL MEDICATIONS
Dihydropyridines Phenylalkelamines Benzodiazepines

amlodipine, anipamil, devapamil, clentiazem, diltiazem

aranidipine, falipamil, gallopamil,
azelnidipine, tiapamil, verapamil.
barnidipine, benidipine,
cilnidipine, clevidipine,
efonidipine, felodipine,
isradipine, lacidipine,
lercanidipine,
manidipine,
nicardipine, nifedipine,
nilvadipine,
nimodipine,
nisoldipine,
nitrendipine,
pranidipine, ryodipine,
trimetazidine.
 Dihydropyridines: Amlodipine
MOA INDICATION CONTRAINDICATION

Amlodipine is Indicated for hypersensitivity,

considered a hypertension, to lower patients with
peripheral arterial blood pressure. Angina cardiogenic shock,
vasodilator that exerts & Coronary Artery severe aortic stenosis,
its action directly on Disease. Treatment of unstable angina,
vascular smooth chronic stable angina, severe hypotension,
muscle to lead to a vasospastic angina heart failure, and
reduction in peripheral (Prinzmetal or variant hepatic impairment.
vascular resistance, angina), and
causing a decrease in angiographically
blood pressure. documented CAD in
patients without heart
failure
 Dihydropyridines: Amlodipine
ADVERSE EFFECT

swelling of the hands, feet, Because it can relieved

ankles, or lower legs. anxiety and significantly
Headache, upset stomach, lower depression risk.
nausea, stomach pain, Inhibition of the renin-
dizziness or angiotensin system may
lightheadedness, have therapeutic potential
drowsiness, excessive effect in mood disorders
tiredness.
Dihydropyridines: Nimodipine
MOA INDICATION CONTRAINDICATION

A peripheral arterial used to treat A previous history of a

vasodilator which acts symptoms resulting hypersensitivity
directly on vascular from a ruptured blood reaction to nimodipine
smooth muscle. vessel in the brain is an absolute
(subarachnoid contraindication. In
hemorrhage). addition, liver failure
and hypotension are
relative
contraindications for
administering
nimodipine.
Dihydropyridines: Nimodipine
ADVERSE EFFECT
Blurred vision, chest pain or
discomfort, difficult or labored
breathing, fast, pounding, or
irregular heartbeat or pulse,
lightheadedness, dizziness, or
fainting, shortness of breath,
slow or irregular heartbeat, and
swelling.
For the improvement of
neurological outcome by
reducing the incidence and
severity of ischemic deficits in
patients with subarachnoid
hemorrhage from ruptured
intracranial berry aneurysms
regardless of their post-ictus
neurological condition
 Dihydropyridines: Isradipine
MOA INDICATION CONTRAINDICATION

decreases arterial Is used alone or a heart attack, severe

smooth muscle together with other disease of the arteries
contractility and medicines (such as of the heart, chronic
subsequent hydrochlorothiazide) to heart failure, low blood
vasoconstriction by treat high blood pressure, liver
inhibiting the influx of pressure problems, fluid
calcium ions through (hypertension). retention in the legs,
L-type calcium feet, arms or hands.
channels
 Dihydropyridines: Isradipine
ADVERSE EFFECT
Dizziness, nausea, headache,
tiredness, flushing, and swelling
of the ankles/feet
Lowering high blood pressure
helps prevent strokes, heart
attacks, and kidney problems.
Isradipine works by relaxing
blood vessels so blood can flow
more easily.
 Phenylalkylamines: Verapamil
MOA INDICATION CONTRAINDICATION

inhibits the calcium ion Verapamil is used Hypersensitivity to

(and possibly sodium alone or together with verapamil or other
ion) influx through other medicines to calcium channel
slow channels into treat heart rhythm blockers, Cardiogenic
conductile and problems, severe shock, Congestive
contractile myocardial chest pain (angina), or heart failure,
cells and vascular high blood pressure Symptomatic
smooth muscle cells. (hypertension) hypotension, Sick
sinus syndrome
(unless permanent
pacemaker in place)
 Phenylalkylamines: Verapamil
ADVERSE EFFECT

Blue lips and fingernails, chest These drugs, especially

pain, coughing that sometimes verapamil, have been
produces a pink frothy sputum, recommended as possible
difficult, fast, noisy breathing, treatments for mania and other
sometimes with wheezing. disorders.
dizziness, faintness, or
lightheadedness when getting up
from a lying or sitting position
suddenly, lightheadedness,
dizziness, or fainting, shortness of
breath.
 Benzodiazepines : Diltiazem, Clentiazem

MOA INDICATION CONTRAINDICATION

inhibits the inflow of aortic stenosis, patients with acute

calcium ions into the bradyarrhythmia/AV myocardial infarction
cardiac, smooth muscle block, cardiogenic and pulmonary
during depolarization. shock/hypotension, congestion and should
Reduced intracellular coronary artery disease, not be used in patients
calcium concentrations liver disease, CHF/AMI, with acute myocardial
equate to increased accessory AV tracts, infarction and
smooth muscle ventricular tachycardia. associated left
relaxation resulting in ventricular dysfunction
arterial vasodilation and, or congestive heart
therefore, decreased failure.
blood pressure
 Benzodiazepines : Diltiazem, Clentiazem

ADVERSE EFFECT

swollen hands, ankles or feet, There was a statistically significant

headaches, feeling dizzy and decrease in the frequency and
lightheaded, feeling tired, weak and severity of both manic and
generally unwell, feeling hot depressive episodes.
(flushing) and redness of the skin,
itching or burning on the skin where
you use the cream or ointment,
stomach pain, indigestion and
constipation.
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