Nutraceutical’s

let food be your

medicine…

Presented By- Prof.Dr.ir.Faisal

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 Content’s

 Introduction

 Dietary supplemants

 Probiotics

 prebiotics

 antioxidants

 Herbal medicines

 Advantage of nutraceutical

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 INTRODUCTION

 The term “Nutraceutical” was coined from

“Nutrition”

“Pharmaceutical” in 1989 by Stephen DeFelice MD, Founder

and Chairman of the Foundation for Innovation in Medicine

(FIM).

“Nutraceutical is any substance that is a food or apart of

food and provides medical or health benefits, including the

prevention and treatment of disease” or promotion of health.

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The nutraceutical’s are associated with the prevention or
treatment of four major diseases like heart disease ,cancer
hypertension and diabetes.

Pharmaceuticals are substances which have (or have had)

patent protection as a result of expensive testing to conform to
the specifications of respective Governments.

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However, many nutrients may never receive government
approval since no one could justify the expense of testing
requirements for substances that cannot be protected by
patent laws. Both pharmaceuticals and nutrients can cure and
prevent disease(s) but only pharmaceuticals have
governmental sanction.

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 DRUG
Disease
treatment
PREVENTI
ON
Health
NUTRACEUTICAL
benefit

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 Advantage of nutraceuticals
Nutraceutical have the potential to play a role in healthy eating
and to contribute to the prevention and treatment of diseases so
that how functional components in foods could expand the role of
disease prevention and treatment.

The nutraceuticals are preferred due to-

Since new molecule is difficult to discover and more expensive

and risky then ever before, many pharmaceutical companies are
now trying to nutraceuticals so that there is undoubtedly a very
huge and growing market .
The belief among consumers that these “food like substances” are
either harmless or least toxic as compared to conventional
pharmaceuticals .
Increased healthcare costs with conventional pharmaceuticals,
recent legislation and scientific discoveries. 7
Inappropriate dietary habits are seen as contributing to the
leading cause of deaths of due to coronary heart disease, certain
type of cancers etc. the role of nutraceuticals in treating these
Conditions is thus speculated.

Nutraceuticals are gaining popularity as people are relying on

them for safeguarding their health and avoiding side effects
associated with drugs as well Long history of use and better
patient tolerance as well as public acceptance Plants constitute to
be a major source of new lead generation.

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 CATEGORIES

DIETARY SUPPLEMENTS Probiotics, Prebiotics, Antioxidants, Enzymes,

etc.

HERBAL/ PHYTOCHEMICALS Herbs or Botanical products.

NUTRIENTS Vitamins, Minerals, Amino Acids, Fatty acids,

etc.

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probiotic
Probiotics are live microbial food ingredients, which are beneficial
to health. Colon is the most densely populated region of the
gastrointestinal tract and harbors an estimated 500 different
bacterial species.

Probiotic bacterial species

The various types of bacteria that are having the probiotics
characteristics are-
Lactobacilli
Lactobacillus rhamnosus
Lactobacillus reuteri
Lactobacillus case
Bifidobacterium breve
Streptococcus

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 PREBIOTICS
 Prebiotics are the substances, which reach to colon in intact form
i.e. without getting depleted by the gastric pH and digestive acids.
These prebiotics also selectively promote the growth of colonel
probiotic bacteria; hence they act as fertilizers for these bacteria.
These are collective term for non-digestive but a fermentable
dietary carbohydrate that may selectively stimulates growth of
certain bacterial groups’ resident in the colon, such as
Bifidobacteria, Lactobacilli considered to be beneficial for the
human host.
inulin, which is soluble dietary fibres and resistant to digestive
enzyme and thus reaches to large intestine or colon essentially
intact, where it is fermented by resistant bacteria, Lactobacilli.

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 ANTIOXIDANTS
Antioxidants are quite large in number and diverse in nature which
inhibit the process of oxidation by neutralizing free radicals .
Dietary antioxidants and some accessory molecules, such as zinc
and certain vitamins are important in maintaining free radical
scavenging systems, biosynthetic capacity, membranes, enzymes .
 Antioxidants are found in the fruits, vegetables and vegetable
oils. eg- Soybean oil, canola oil, corn oil, oat oil, wheat germ oil,
palm oil.

Like tocopherols (vitamin E) lower the LDL oxidation and also

reduce platelet’s role in thrombus formation. 15
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Obsessive-compulsive disorder (OCD)
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Classification of antioxidants

Vitamins Vitamin C, vitamin E

Carotenoids β-Carotine, lycopine

Thiols lipoic Acid, glutathione (efficient radical scavengers )

Enzymes Co-Enzyme Q-10, super oxide dismastase

Minerals, copper, manganese, zinc Selenium

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 Herbals:
 Aloe vera: Anti-inflammatory, emollient, wound healing,

 Garlic: Antibacterial, antifungal, antithrombotic, antiinflammatory,

 Ginger: carminative action, antiemetic, treatment of dizziness

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 Ginseng: Adaptogen,(i.e. Prevention from stress effect).
its antioxidant and anti-inflammatory effects. It could have
benefits for some cancers. ginseng may strengthen the immune
system, enhance brain function, fight fatigue and improve
symptoms of erectile dysfunction

 Green tea: Antioxidant, reduces risk of CVD, enhances humoral and

cell mediated Immunity,

Vegetables, fruits, whole grain, herbs, nuts and various seeds contain
an abundance of phenolic compounds, terpenoids, sulphur compounds,
pigments etc. that has been associated with protection / treatment of
certain disease conditions,

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 Phytochemicals:
Phytochemicals could provide health benefits as:
1. Substrate for biochemical reactions
2. Cofactors of enzymatic reactions
3. Inhibitors of enzymatic reactions
4. Absorbents that bind to & eliminate undesirable constituent in the
intestine.
5. Scavengers of reactive or toxic chemicals

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Various Phytochemicals
Phytochemicals Source Role

Tocotrienols & Grains Suppressed the growth of diverse

tocopherols tumors cell lines via initiation of
apoptosis and concomitant arrest of
cells in the G1 phase of the cell
cycle

Carotenoids Fruits & Antioxidants, protects against

uterine, prostate, colorectal, lung
vegetables
and digestive tract cancers, and
protection to other antioxidants.

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Flavonoids Grapes, wines Action against free radicals, free
radicals mediated cellular
signaling, inflammation,
allergies, platelet aggregation, &
hepatotoxins

Catechin & gallic Grapes, berries, Antioxidants, free radical

acids cocoa, green tea, scavenging ability, inhibition of
acacia spp. eicosanoid synthesis, reduces
CHD

Isoflavonoids Soybeans Treating cancers & osteoporosis

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 Vitamins like Compounds
 L- Carnitine: an amino acid derivative that transports fatty
acids into your cells to be processed for energy. Helps in
oxidation of fatty acids, role in oxidative phosphorylation.

 Choline: Lipotropic agent,(i.e. Endogenous factors or drugs that

increase the transport and metabolism of LIPIDS) used to treat fatty
liver and disturbed fat metabolism . The body needs choline to
synthesize phosphatidylcholine and sphingomyelin,

 Inositol: it mediates cell signal transduction in response to a variety

of hormones, neurotransmitters, and growth factors. Improving
some anxiety disorders and your body's sensitivity to insulin.

Taurine: Helps in retinal photoreceptor activity, bile acid conjugation, WBC

antioxidant activity, CNS neuromodulation, platelet aggregation, cardiac

contractibility, sperm motility, insulin and metabolic activity, 26
 Minerals:
Calcium: essential for bone and teeth, maintaining bone strength,
nerve, muscle and glandular function, blood clotting,

 Iron: energy production, Hb, oxygen transport,

 Magnesium: for healthy nerve and muscle function, bone

formation,

Phosphorous: energy production, phosphorylation process, bone and

teeth, for genetic material,

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NUTRACEUTICALS AVAILABLE IN MARKET
Brand name Components Function

Betatene Carotenoids Immune function

Xangold Lutein esters Eye health

Lipoec -lipoic acid Potent antioxidant

Generol Phytosterol CHD reduction

Premium probiotics probiotics Intestinal disorder

Soylife Soyabean Bone health

phytoestrogen
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Brand name Components Function

Z-trim Wheat Zero calorie fat replacer

Linumlife Lignan extract flax Prostate health

Fenulife Fenugreek Control blood sugar

galactomannon

Teamax Green tea extract Potent antioxidant

Marinol  3 FA, DHA, EPA Heart health protection

Clarinol CLA Weight loss ingredient

Cholestaid Saponin Reduce cholesterol

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APPLICATIONS OF NUTRACEUTICALS

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Class /components source Potential benifit
Beta-carotene Carrots, various fruits Neutralizes free
radicals, which may
damage
cells; bolsters
cellular
antioxidant
defenses
May contribute to
Lycopene Tomatoes
maintenance of
prostate

Monosaturated fatty Tree nuts May reduce risk of

acids coronary heart disease

Flavonols Onions, apples, tea,

broccoli Neutralize free radical,
which may damage
cells;bolster
cellular,antioxidation
defences 28
Soy protein Soybeans and soy- May reduce risk of coronary
based food
heart disease

Lactobacilli, Yogurt, other dairy and May improve

gastrointestinal
bifidobacteria nondairy applications health and systematic
immunity

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