Paget's disease

Prepared the presentation

Student 305-MN
Victoria Shymchenko
 Aboute paget's disease
Paget's disease of the bones refers to diseases of the skeleton or bone dysplasia,
manifested in a violation of the structure of bone and connective tissue.The bone loses its
supporting functions and is easily deformed under the influence of loads, which leads to:

 to curvatures of the spine, limbs;

 violation of the anatomical proportions of the skull;
 to painful neurological disorders;
 fractures;
 transformation of the center into a sarcoma;
 other consequences and complications.
 What causes Paget's disease:

• congenital disorders of connective bone synthesis;

• endocrinological disorders;
• autoimmune processes;
• neoplastic bone dysplasia;
• viral diseases (eg, measles).
 Clinical signs of Paget's disease of the bones

• Externally, Paget's disease manifests itself in the following

symptoms:
 Aching pains in the bones.
 In the soft tissues located above the pathological bone area, there is an increase in temperature (hyperthermia) caused by
dilation of blood vessels in the cells.
 X-ray shows microfractures in areas of pathology.
 In the later stages, pathological transverse fractures of the bones begin.
 Defeat of skeletal departments of asymmetric type:
 at localization b. Paget in the spine - kyphosis, scoliosis;
 in tubular bones - varus or valgus deformity of the femur and tibia;
 in a skull - deformation of a frontal part and the basis, thickening of bones in two - three times.
 To diagnose:
• examination in the doctor's office;
• radiography;
• scintigraphy using a radioactive contrast agent;
• blood tests to determine the level of alkaline phosphatase, calcium
and phosphorus;
• urine analysis for the presence of oxyproline;
• bone puncture.
 How to treat Paget's bone disease
Mainly symptomatic (analgesic) and maintenance therapy, which slows down destructive changes and
deformities in the bones and prevents fractures.
Drug treatment
The patient is prescribed:
nonsteroidal drugs;
steroid hormonal drugs (glucocorticoids, anabolic steroids, androgens);
thyroid hormone calcitonin,
biophosphonates (zolendronate, tiludronate, alendronate, residronate);
preparations containing iodine;
antitumor antibiotics (eg, plicamycin);
salicylates;
calcium preparations, simultaneously with vitamin D; vitamin and mineral complexes, etc. medicine.
Prescribing the drug by a doctor is carried out in accordance with the presumed cause of the disease,
symptoms and the presence of resistance