CELDRIN

(Celadrin 500mg, Glucosamine 500mg)

Joints:
• A joint or articulation (or articular surface) is the connection made
between bones in the body which link the skeletal system into a functional
whole. They are constructed to allow for different degrees and types of
movement.
• Some joints, such as the knee, elbow, and shoulder, are self-lubricating,
almost frictionless, and are able to withstand compression and maintain
heavy loads while still executing smooth and precise movements.
• Other joints such as sutures between the bones of the skull permit very
little movement (only during birth) in order to protect the brain and the
sense organs.
Joint pain
• Any damage to the joints from disease or injury can interfere with
movement and cause a lot of pain. Many different conditions can lead to
painful joints, including
Osteoarthritis
 Rheumatoid Arthritis,
bursitis,
gout,
strains,
sprains, and other injuries.
• Joint pain is extremely common.
 Click icon to add picture
Osteoarthritis
Osteoarthritis (OA) is the most
common joint disorder. OA occurs
when the cartilage between two
joints wears down so the bones rub
together, resulting in swelling and
stiffness.
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Rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune
disease that can cause joint pain and damage
throughout your body. The joint damage that
RA causes usually happens on both sides of the
body. So, if a joint is affected in one of your
arms or legs, the same joint in the other arm or
leg will probably be affected, too.
Treatment
 Celdrin
• Celadrin is a natural anti-inflammatory compound that
people use for arthritis, to improve joint function and
mobility.
• It is a mixture of cetylated fatty acids, which are formed by
combining naturally occurring fats with cetyl alcohol.
 glucosamine
• Glucosamine is an amino sugar and a prominent precursor in the biochemical
synthesis of glycosylated proteins and lipids.
• Glucosamine is one of the most abundant monosaccharides.
• Glucosamine is used by the body to make other chemicals that build tendons,
ligaments, cartilage, and the fluid that surrounds joints.
• Joints are cushioned by the fluid and cartilage around them.
• Taking glucosamine might increase the cartilage and fluid around joints and/or
help prevent their breakdown.
 Mechanism of action:
Celadrin acts to reduce inflammation and pain by:
• Reducing the production of inflammatory compounds, prostaglandins
(by blocking the COX-2 enzyme).
• Reducing the release of chemicals that increase inflammation from
white blood cells (leukotriene B4 and interleukin-1).
• Reducing tissue damage by blocking the enzyme (thromboxane-A
synthase) that increases inflammation.
• Regenerating cartilage and improving joint health.
• It protects cartilage from damage and provides more cushioning for
the joint, according to a patent filed by the Life Science company.
• Celadrin systematically enhances and lubricates cell membranes
throughout the body providing youthful cell fluidity and elasticity.
• This includes the enhancement of fluids that cushions your bones
and joints to maintain flexibility and mobility so that you can move
with ease and pain free.
 How Celadrin And Glucosamine Work
Together
• Inflammation, insufficient lubrication, and lack of cell membrane fluidity
can cause wear on the joint area.
• Glucosamine is clinically studied. It increases the range of motion and
relieves pain at the same rate of Ibuprofen.
• Glucosamine assists in rebuilding cartilage and the overall structure of the
joint. However, it’s shown moderate effects on people affected by
osteoarthritis.
• Celadrin actually lubricates the cell membrane continuously, enabling the
cell membrane to repel inflammatory chemicals.
• Celadrin stops the cascade of inflammation and assaults on the
membrane, which cause it to stiffen.
• Celadrin empowers glucosamine to perform faster and more efficiently
in building joint cartilage.
• The synergistic dual-action of Celadrin & glucosamine provides rapid
joint cushioning, quickly alleviating inflammation, building cartilage
and restoring the entire joint area.

• Glucosamine and Celadrin may inhibit platelet aggregation in some

individuals via aspirin-like effects as well as inhibition of ADP receptor
P2Y1 but not P2Y12.
 Indications:
• Osteoarthritis: Celadrin cream reduced pain, improved posture, and increased
standing stability in 40 patients after 30 days of treatment.
• Muscle Pain: In a study of 72 patients with chronic neck pain, using Celadrin
twice daily with physical therapy reduced pain and improved neck mobility.
• Blood Clotting: When combined with glucosamine, Celadrin prevented the
formation of blood clots (by preventing platelet clumping) in 24 healthy
subjects. This effect may protect the heart and blood vessels and reduces the
chances of heart attack and stroke.
• Psoriasis: In a small pilot study of psoriasis patients, Celadrin improved the
symptoms such as skin scales, patchiness, redness, dryness, cracks, and raised
skin.
• Fibromyalgia: In a non-controlled study of 13 patients with fibromyalgia, cetyl
myristoleate (the main component of Celadrin) reduced pain, fatigue, and
sleep disturbances caused by the disease.
 DOSAGE FORMS, STRENGTH AND
PACKAGING
• Product Packing TP MRP
• Celdrin 30s 1147.5 1350

The typical oral dosage of Celadrin is 1,000-1,500 mg daily.

Take 1-2 tablets daily or as directed
by the physician
 Side effects and precautions:

No major side effects were reported in clinical trials for both topical and oral
Celadrin.

Some people may be allergic to Celadrin; two fibromyalgia patients withdrew

from a trial after experiencing indigestion and developing rashes .
There is no safety data about dosage in young children, pregnant or nursing
women, and people with severe liver or kidney disease.
 These sensitive groups should avoid Celadrin just in case.
 Interactions:

•Using Celadrin with blood thinners should be avoided

as both reduce blood clotting, which may, in theory,
lead to uncontrollable bleeding. However, this
interaction has not been studied yet.
90,000,000 celadrin pills distributed to date in USA,
no evidence of drug related side effects reported.
(San Diego-based Imagoyhjnenetix, inc,
Www.Imagenetix.Net)
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RHEUMATOLOGIST
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