Instructional Materials; Intro

I. What is Osteoporosis?
As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of
becoming a world-top company and seeks after healthy life of human beings through con-
tinued technology innovation and challenges.

www.osteosys.com 1
Instructional Materials; Intro

I. What is Osteoporosis?
1. Definition of Term
Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.
In Latin, ‘Osteoporosis’ means ‘hollowed bone symptom’, and it is same for many modern languages.

Osteo Normal Bone

porosis

Ostéo
Остеопороз
porose

Hollowed
Bone Osteoporosis
骨粗鬆症 骨多孔症

骨质疏
골다공증 松症

Images from L. Mosekilde, Technology and Health Care. 1998 2

Instructional Materials; Intro

I. What is Osteoporosis?
2. Why Osteoporosis Happens?
Human bone repeats a cycle of creation and destruction.
Osteoporosis is due to slow bone production and fast bone loss.
When the balance between resorption(osteoclast) and formation(osteoblast)is broken…

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Images from https://3c1703fe8d.site.internapcdn.net/newman/gfx/news/hires/2017/noncodingrna.jpg
Instructional Materials; Intro

I. What is Osteoporosis?
2. Why Osteoporosis Happens?
Women’s bone is aging faster especially after menopause.
This leads to great danger of fracture, and collapse your life.

35
25
Bone Density

Menopause
18

Fracture Threshold

Age
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Instructional Materials; Intro

I. What is Osteoporosis?
3. Why Osteoporosis is Dangerous?
Osteoporosis itself has no symptoms, but its main consequence is the increased risk of fractures.
Lack of bone density leads to collapse of whole body structure.

BONE

Osteoporosis is fatal disease.

It is like a mine planted in your body, and when there is some shock...
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Instructional Materials; Intro

I. What is Osteoporosis?
3. Why Osteoporosis is Dangerous?
Debilitating acute and chronic pain in the elderly is often attributed to fractures
and can lead to further disability and early mortality.

Most frequent osteoporotic fracture

Consequences of
Hip Fracture
100%

80%
80%
60%

40%
40%
20% 30%
20%
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Image Source: National Osteoporosis Foundation, Washington, DC

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Data Source: Cooper. Am J Med 1997; 103(2A): 12s-19s

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Instructional Materials; Intro

I. What is Osteoporosis?
3. Why Osteoporosis is Dangerous?
Osteoporotic fractures can be happened anywhere, anytime.
It happens more often than heart attack or stroke.

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Instructional Materials; Intro

I. What is Osteoporosis?
3. Why Osteoporosis is Dangerous?

Osteopenia & Os- Osteopenia & Os-

teoporosis teoporosis
Prevalence Rate Age over 50
Osteoporosis + Osteopenia
Prevalence Rate Age over 50
Osteoporosis + Osteopenia

(Women) (Men)
8 out of 10 women suffer from 5 out of 10 men suffer from
osteopenia or osteoporosis. osteopenia or osteoporosis.

Normal Normal
Osteopenia Osteopenia
Osteoporosis Osteoporosis

Source: National Health Stastics 2008

4th Korea National Health and Nutrition Examination Survey 2008

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Instructional Materials; Intro

I. What is Osteoporosis?
3. Why Osteoporosis is Dangerous?

Osteoporosis
Prevalence Rate of
Awareness and
Cure Rate people could be cured on time
Fraction
8 out of 10 female osteoporosis patient
Female Male

Incidences (per 10,000 capita) 2008

were not diagnosed well, Age of 60; Vertebra Vertebra
and 9 out of 10 could not be cured. Awareness rate Age of 70; Femur Clavicle
Furthermore, 9 out of 10 male patient Cure rate Humerus
could not be diagnosed nor cured. Carpal
Tarsus
Femur

Source: ‘A Study on the Medical

Utilization and Prescription Pattern
of Osteoporosis’
The Health Insurance Review and
Source: National Health Stastics 2008
Assessment Service, Korea 2009
4th Korea National Health and Nutrition Examination Survey 2008
Age Group

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Instructional Materials; Intro

I. What is Osteoporosis?
3. Why Osteoporosis is Dangerous?

1 Year Mortality Population of Total

after Femur Fraction Femur Fraction 1950 1.66 mil

2050 6.26 mil
Patient (est. 2050)
Estimation of worldwide osteoporotic femur fraction
35% of male femur fraction patient (thousand people)
over 70 years old pass away within a year
Male Female
1 year mortality (2007, %)

Age Group

Source: ‘A Study on the Medical

Utilization and Prescription Pattern Asia
of Osteoporosis’ 1950 0.57 mil
The Health Insurance Review and
2050 3.25 mil
Assessment Service, Korea 2009

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Instructional Materials; Intro

I. What is Osteoporosis?
4. How Can We Prevent Osteoporosis?
Lifestyle prevention of osteoporosis is the inverse of the modifiable risk factors.
But also timely diagnosis is really important factor,
because 90% of people could not be diagnosed nor cured.

35
25
Bone Density

Menopause
18

Good lifestyle and

timely diagnosis Age

can prevent serious osteoporosis.
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Instructional Materials; Intro

I. What is Osteoporosis?
5. How to Diagnose Osteoporosis?
Bone mineral density (BMD) has to be measured by more specialized techniques,
and that is what Osteosys is researching.

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Instructional Materials; Intro

I. What is Osteoporosis?
6. T-Score & Z-Score
The T-Score is a comparison of a patient's BMD to that of a healthy 30-year-old.
The Z-score is the comparison to the age-matched normal and is usually used in cases of
severe osteoporosis.

Age of 50
Z-Score or menopause T-Score

1.5

Non -Osteoporotic
1

0.5

0 (normal)
-0.5

T-Score -1 SD
-1

-1.5

-2
osteopenia
-2.5

-3 severe
// T-Score -2.5 SD
-3.5 osteoporosis osteoporosis
-4

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Instructional Materials; Intro

I. What is Osteoporosis?
7. Osteosys against Osteoporosis
We provide the most cost-effective T-score measurement solution, and more.
The company name itself explains what we are looking for.
We want to get rid of ‘pore’ from your bone.

Osteoporosis

Better product for better life

9F, JnK Digital Tower, 111 Digital-ro 26, Guro Seoul Korea
T: +82 2 6124 5900 F: +82 2 6124 5958 E: info@osteosys.com 14