ASSIGNMENT ; BASIC MEDICAL

SCIENCES
TOPIC : DISORDERS
Ha OF WHITE
BLOOD CELLS
SUBMITTED BY; SANA FATIMA
(MSPT-229)
SUBMITTED TO : DR SARAH
EIJAZ
 DISORDERS OF WHITE BLOOD CELLS

• Two major types of white blood cell disorders are proliferative disorders and leukopenias
1. Leukopenias
2. Leukocytosis( proliferative disorder).
In leukopenias, there is a decrease in the number of white blood cells, which can be caused by cells being
destroyed by an illness or by other conditions.
One particular kind of leukopenia is neutropenia, which means that there are fewer neutrophils in the blood.
Outside causes of neutropenia include chemotherapy, medications, toxins, and viral illness. Disorders that can
cause neutropenia within the body include defects in bone marrow (where all WBCs are created), or conditions in
which a person is born with too few neutrophils.
Both leukopenia and neutropenia can cause deficiency in the immune system, which can increase risk of infection
In the proliferative disorders, there is an increase in the number of white blood cells. This increase is commonly a
reaction due to infection, but may, less commonly, be related to some types of cancer.
 LEUKOPENIA

• Too few or too many white blood cells indicates a disorder. Leukopenia, a
decrease in the number of white blood cells to fewer than 4,000 cells per
microliter of blood (4 × 109 per liter), frequently makes people more
susceptible to infections. It is a common form of white blood cell disorders.
 LEUKOCYTOSIS

• Leukocytosis, an increase in the number of white blood cells to more than

11,000 cells per microliter of blood (11 × 109 per liter), is often caused by the
normal response of the body to help fight an infection, or to some drugs such as
corticosteroids.
• However, an increase in the number of white blood cells is also caused by
cancers of the bone marrow (such as leukemia) with the release of immature or
abnormal white blood cells from the bone marrow into the blood.
 TYPES OF LEUKOCYTOSIS

1. Neutrophilia
2. Lymphocytosis
3. Basophilia
4. Eosinophilia
5. Monocytosis
• There are five types of leukocytes therefore there are five types of
leucocytosis, each type occurs due to the increase in the number of specific
leucocyte.